133554-24-2Relevant articles and documents
4 - [6 - (methylthio) benzo [1,2-d:5,4-d '] b [1,3] oxazole-2-yl] benzoic acid and its preparation method
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Paragraph 0034-0036, (2017/02/28)
The invention discloses 4-[6-(methylthio) benzo [1, 2-d: 5, 4-d']-di-[1, 3] oxaxole-2-yl] benzoic acid and a preparation method thereof. The preparation method comprises the steps as follows: resorcinol is taken as a raw material and subjected to sulfonation, nitration, hydrolysis and reduction to obtain 4-amino-6-nitroresorcinol hydrochloride; ANR*HCl and p-methoxycarbonyl benzoyl chloride (MBC) are subjected to condensation, cyclization and dehydration to obtain 4-(6-hydroxy-5-nitrobenzo[d]oxazole-2-yl) methyl benzoate; NHABE is subjected to hydrogenation reduction under the action of a Pd/C catalyst to obtain 4-(6-hydroxy-5-aminobenzo[d]oxazole-2-yl) methyl benzoate; AHABE and CS2 are subjected to cyclization under the alkaline condition to obtain 4-(6-(mercapto)benzo[1, 2-d:5, 4-d']-di-(oxazole)-2-yl) benzoic acid; and dimethyl methyl sulfate is compounded to the target compound 4-[6-(methylthio) benzo [1, 2-d: 5, 4-d']-di-[1, 3] oxaxole-2-yl] benzoic acid. According to the invention, a novel compound is obtained, the method is simple and convenient, and the product yield is high.
