133602-38-7

Upstream product

• 133602-34-3 N-(3-Carbethoxypropanoyl)-ω-aminoacetophenone 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 5468-37-1 2-aminoacetophenone hydrochloride 

Downstream Products

• 23485-68-9 3-(5'-Phenyl-2'-oxazolyl)propanoic Acid 
• 133602-41-2 N'-Carbethoxy-2-(5'-phenyl-2'-oxazolyl)propanoic Hydrazide 
• 133602-45-6 2,3,5,6-Tetrahydro-5-oxo-2-benzoyl-3-carbethoxy-1,2,4-triazolo<2,3-a>pyrrole 

Relevant academic research and scientific papers

Beta lactam compounds and their use as inhibitors of tryptase

Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.

Novel Heterocycles by Bis Heteroannulation of Oxazoles

We report the first examples of intramolecular Diels-Alder addition of heterodienophiles N=N, C=N, C=O, C=S to oxazoles.The required 5-ethoxy- and 5-phenyloxazoles were synthesized bearing a side chain of variable length on C-2 to which the different heterodienophiles are attached.The products of the thermal bis heteroannulation are 3-triazolines, imidazolines, oxazolines, or thiazolines fused to a five- to six-membered ring.Relative reactivities were established and the mechanism is discussed.