13362-77-1Relevant articles and documents
Structural variation of transition metal coordination polymers based on bent carboxylate and flexible spacer ligand: Polymorphism, gas adsorption and SC-SC transmetallation
Pal, Arun,Chand, Santanu,Senthilkumar,Neogi, Subhadip,Das, Madhab C.
, p. 4323 - 4335 (2016)
Reaction of the bent dicarboxylate ligand H2OBA (H2OBA = 4,4′-oxybisbenzoic acid) and the flexible linker 1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene (L1), under diverse reaction conditions, forms two polymorphic Co(ii) coordination polymers (CPs): {[Co(OBA)(L1)]·DMF}n (1), as a three dimensional (3D) framework with a pcu alpha-Po primitive cubic topology, and {[Co(OBA)(L1)]·DMF}n, (2), as a two dimensional (2D) structure with a 6-c uninodal net topology. Gas adsorption measurements of the desolvated Co(ii) CPs show negligible uptake of all gases in 1, while 2 exhibits moderate uptake of CO2, with good selectivity over N2 and CH4. With Zn(ii), reaction of H2OBA and L1 produces a different 2D CP, {[Zn0.5(OBA)0.5(L1)0.5]}n (3). Finally, three isostructural Cd(ii) CPs, {[Cd(OBA)(L1)]·DMF}n (4), {[Cd(OBA)(L1)]·DEF}n (5), and {[Cd(OBA)(L1)]·DMA}n (6) (DMF = N,N-dimethylformamide, DEF = N,N-diethylformamide, DMA = N,N-dimethylacetamide), that differ only in the lattice solvent molecules and show 2D structural arrangements are prepared. Interestingly, CP 4 undergoes single-crystal to single-crystal (SC-SC) transmetallation reaction at room temperature, yielding isostructural {[Cu(OBA)(L1)]·DMF}n (7) that cannot be synthesized independently. Moreover, the luminescence properties of compounds 1, 2, 3, and 4 have been studied in the solid state at room temperature. All the complexes are characterized by elemental analysis, IR, TGA, PXRD and single crystal X-ray diffraction.
Structural diversity in six mixed ligand Zn(II) metal-organic frameworks constructed by rigid and flexible dicarboxylates and different N, N′ donor ligands
Halder, Arijit,Bhattacharya, Biswajit,Haque, Fazle,Ghoshal, Debajyoti
, p. 6613 - 6624 (2017)
Three different N, N′-donor ligands with Zn(NO3)2·6H2O and two different dicarboxylates, flexible succinate (suc) and rigid fumarate (fum) afforded six different metal-organic frameworks (MOFs). Among the N, N′-donor ligands, one bent 1, 4-bis(3-pyridyl)-2, 3-diaza-1, 3-butadiene (3-bpdb) gives two isostructural two-dimensional MOFs, {[Zn(3-bpdb)(suc)]·(H2O)2}n (1) and {[Zn(3- bpdb)(fum)(H2O)2]}n (2). The use of a straight N, N′-donor ligand, i.e., 1, 4-bis(4- pyridyl)-2, 3-diaza-1, 3-butadiene (4-bpdb), results in two three-dimensional (3D) MOFs, {[Zn4(4-bpdb)2(suc)3(OH)2]·5(H2O)}n (3) and {[Zn(4-bpdb)(fum)]·(H2O)2}n (4). Here, 3 is a pillared layer structure, whereas 4 has a 5-fold interpenetrated dimondoid network. For both the bent and straight N, N′-donor ligands an imine alike motif is embedded in the structure. When this motif is replaced by a C-C double bond by using the ligand 1, 2-bis(4-pyridyl)ethylene (bpee), it produces two MOFs, {[Zn(bpee)(suc)]2·(H2O)3}n (5) and {[Zn2(bpee)2(fum)2]·(H2O)}n (6), having a similar structural relation like 3 and 4 respectively, 5 with a pillared layer structure and 6 with a 5-fold interpenetrated diamondoid network. All the compounds have been thoroughly characterized by powder X-ray diffraction (PXRD), elemental analysis, infrared (IR) spectroscopy, UV-vis spectroscopy, and thermogravimetric analyses. Gas/solvent vapor sorption studies have been carried out for compounds 3-6, which have 3D structures. In the case of 3, an interesting reversible crystalline to crystalline transformation was observed which has been thoroughly studied by PXRD analysis, IR spectroscopy, and UV-vis spectroscopy. Solid state emission spectral analysis for all the complexes was performed at room temperature.
Design, synthesis and biological evaluation of Schiff’s base derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Shi, Jian,Zhou, Yi,Wang, Keren,Ma, Qinge,Wei, Rongrui,Li, Qingfeng,Zhao, Yiyang,Qiao, Zhanpin,Liu, Shuang,Leng, Yumin,Liu, Wenmin,Sang, Zhipei
, p. 624 - 634 (2020/11/30)
A series of Schiff’s base derivatives was rationally designed, synthesized, and evaluated as multi-function agents for the treatment of Alzheimer’s disease (AD). The results revealed that compound 3b was a novel multifunctional agent. It acted as a highly selective monoamine oxidase-B inhibitor (IC50 = 8.4 nM), which was explained by the docking study. Compound 3b also was an antioxidant agent (2.3 eq) and could significantly inhibit self-induced Aβ1-42 aggregation (31.8%). Meanwhile, compound 3b was a selective metal chelator and could inhibit Cu2+-induced Aβ1-42 aggregation (62.3%). Furthermore, compound 3b presented good neuroprotective effects on H2O2-induced PC12 cell injury. More importantly, compound demonstrated good blood brain barrier permeability and druglike properties. Therefore, compound 3b, a promising multi-targeted active molecule, offers an attractive starting point for further study in the drug-discovery process against AD.[Figure not available: see fulltext.].
