13363-50-3

Basic information

• Product Name: BIPHENYL-4-CARBOTHIOIC ACID AMIDE
• Synonyms: BIPHENYL-4-CARBOTHIOIC ACID AMIDE;Biphenyl-4-thiocarboxaMide, 97%;4-biphenylthio Carboxamide;4-BiphenylthioaMide;4-Phenylthiobenzamide;4-phenylbenzenecarbothioamide
• CAS NO: 13363-50-3
• Molecular Formula: C₁₃H₁₁NS
• Molecular Weight: 213.3
• Mol File: 13363-50-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 227-232°C
• Boiling Point: 370.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.176±0.06 g/cm3(Predicted)
• PKA: 13.07±0.29(Predicted)
• CAS DataBase Reference: BIPHENYL-4-CARBOTHIOIC ACID AMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIPHENYL-4-CARBOTHIOIC ACID AMIDE(13363-50-3)
• EPA Substance Registry System: BIPHENYL-4-CARBOTHIOIC ACID AMIDE(13363-50-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-41-50
• Safety Statements: 26-39-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 13363-50-3(Hazardous Substances Data)

Usage

Uses

Biphenyl-4-thiocarboxamide is a synthetic intermediate useful for pharmaceutical synthesis.

Upstream product

• 92-92-2 biphenyl-4-carboxylic acid 
• 3815-20-1 biphenyl-4-carboxylic acid amide 
• 3218-36-8 4-Phenylbenzaldehyde 
• 98-80-6 phenylboronic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 2920-38-9 4-cyano-1,1'-biphenyl 

Downstream Products

• 328919-73-9 (2-biphenyl-4-yl-5-methyl-thiazol-4-yl)-acetic acid methyl ester 
• 1303709-11-6 1-[4-methyl-2-((1,1′-biphenyl)-4-yl)thiazol-5-yl]ethanone 
• 1537168-43-6 2-{1-[2-([1,1′-biphenyl]-4-yl)-4-methylthiazol-5-yl]-ethylidene}hydrazinecarboximidamide 
• 131786-84-0 2-(4-biphenyl)-4-hydroxy-5-phenylthiazole 

Relevant articles and documents

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant burden both clinically and economically worldwide. Increasing resistance to current antibiotics requires an urgent investigation into novel classes of antimicrobial agents. This study presents a structure–activity relationship (SAR) rationale for pyrazole linked phenylthiazole analogues as new antibacterial agents. A library of 23 novel pyrazole linked phenylthiazole compounds were synthesised, followed by screening for antimicrobial activity against five bacterial species and two fungi. The most active compound 14b has shown promising antibacterial activity against the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA, ATCC 43300) strain (MIC 4 μg/mL). Furthermore, the active pyrazole linked phenylthiazole compound exhibited a better toxicity profile than standard antibiotics. In summary, these results demonstrate that a pyrazole linked phenylthiazole scaffold has potential as a lead for further investigation to afford novel antibacterial agents.

A simple method for synthesis of thioamides and application in synthesis of 1,2,4-thiadiazoles

A novel, simple protocol is disclosed for the synthesis of 1,2,4-thiadiazoles starting from thioamides with Na2-eosin Y-sensitized titanium dioxide as catalyst through visible light irradiation (7 W blue LED light) and only 0.3 mol% catalysts were used. The raw material thioamides is prepared by aryl nitriles and sodium sulfide (Na2S9H2O) in DMF and in this reaction, readily available, inexpensive inorganic salt (Na2S9H2O) serves as the sulfur source and various functional groups of aryl nitriles were well and thioamides were synthesized successfully in gram-scale.

ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE

Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.