13364-95-9 Usage
Uses
Used in Pharmaceutical Research:
2-(methylamino)adenosine is used as a biochemical tool for studying the effects of adenosine receptors, aiding in the understanding of their role in various physiological processes and potential therapeutic targets.
Used in Anti-inflammatory Applications:
2-(methylamino)adenosine is used as an anti-inflammatory agent, demonstrating its potential to reduce inflammation in certain cellular and animal models, which could be beneficial in treating inflammatory conditions.
Used in Anti-fibrotic Applications:
2-(methylamino)adenosine is used as an anti-fibrotic agent, showing promise in preventing or reducing fibrosis in certain tissues, which could be applied in the treatment of fibrotic diseases.
Used in Diabetes Treatment:
2-(methylamino)adenosine is used as a potential therapeutic agent for diabetes, where it may help in managing blood sugar levels and improving overall metabolic health.
Used in Cardiovascular Disease Treatment:
2-(methylamino)adenosine is used as a potential therapeutic agent for cardiovascular disease, where it may contribute to the prevention or treatment of conditions affecting the heart and blood vessels.
Used in Cancer Therapy:
2-(methylamino)adenosine is used as a potential therapeutic agent in cancer treatment, where it may help in inhibiting tumor growth and progression, and could be used in combination with conventional chemotherapy to enhance treatment efficacy.
Used in Neurological Disorders Research:
2-(methylamino)adenosine is used as a research compound to study its ability to modulate neurotransmitter release, which could have implications for the treatment of neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 13364-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,3,6 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13364-95:
(7*1)+(6*3)+(5*3)+(4*6)+(3*4)+(2*9)+(1*5)=99
99 % 10 = 9
So 13364-95-9 is a valid CAS Registry Number.
13364-95-9Relevant academic research and scientific papers
Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors
Tatani, Kazuya,Hiratochi, Masahiro,Nonaka, Yoshinori,Isaji, Masayuki,Shuto, Satoshi
supporting information, p. 244 - 248 (2015/03/30)
Purine-rich foods have long been suspected as a major cause of hyperuricemia. We hypothesized that inhibition of human concentrative nucleoside transporter 2 (hCNT2) would suppress increases in serum urate levels derived from dietary purines. To test this hypothesis, the development of potent hCNT2 inhibitors was required. By modifying adenosine, an hCNT2 substrate, we successfully identified 8-aminoadenosine derivatives as a new class of hCNT2 inhibitors. Compound 12 moderately inhibited hCNT2 (IC50 = 52 ± 3.8 μM), and subsequent structure-activity relationship studies led to the discovery of compound 48 (IC50 = 0.64 ± 0.19 μM). Here we describe significant findings about structural requirements of 8-aminoadenosine derivatives for exhibiting potent hCNT2 inhibitory activity.
