133643-28-4Relevant academic research and scientific papers
Chiral aminal templates: Diastereoselective addition to hydrazones; an asymmetric synthesis of α-amino aldehydes
Alexakis,Lensen,Tranchier,Mangeney,Feneau-Dupont,Declercq
, p. 1038 - 1050 (2007/10/02)
The monohydrazone of glyoxal may be derivatized into a chiral aminal with diamine 7. The resulting chiral reagent 13 reacts with complete diastereocontrol with organolithium reagents in THF. This sterically controlled reaction may be altered to chelation
CHIRAL AMINAL TEMPLATES 6. DIASTEREOSELECTIVITY OF HYDRAZONE ALKYLATION. ASYMMETRIC SYNTHESIS OF α-AMINOALDEHYDES
Alexakis, Alexandre,Lensen, Nathalie,Mangeney, Pierre
, p. 1171 - 1174 (2007/10/02)
Glyoxal is efficiently transformed into the chiral aminals bearing the hydrazone functionality 2a and 2b.These compounds react under complete diastereocontrol with various organolithium reagents, affording chiral hydrazines 3-9.Reduction with Raney nickel
