133671-49-5Relevant academic research and scientific papers
New triple-helix DNA stabilizing agents
Strekowski, Lucjan,Hojjat, Maryam,Wolinska, Ewa,Parker, Alesia N.,Paliakov, Ekaterina,Gorecki, Tadeusz,Tanious, Farial A.,Wilson, W.David
, p. 1097 - 1100 (2007/10/03)
Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA·2polydT and duplex polydA·polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T·A·T triplets and triple/duplex selectivity were designed through a rational approach.
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents
Strekowski,Mokrosz,Honkan,Czarny,Cegla,Wydra,Patterson,Schinazi
, p. 1739 - 1746 (2007/10/02)
Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized with use of novel chemistries developed by us recently. Some of these derivatives show anti-HIV-
