3762-94-5

Usage

Type of compound

Heterocyclic organic compound

Structure

Contains both sulfur and nitrogen atoms

Common use

Building block in the synthesis of pharmaceuticals and agrochemicals

Functional groups

Carboxylic acid groups

Versatility

Can form coordination complexes with metal ions

Applications

Useful in various industrial and research applications

Biological activities

Being studied for potential medicinal properties

InChI:InChI=1/C4H2N2O4S/c7-3(8)1-2(4(9)10)6-11-5-1/h(H,7,8)(H,9,10)

Upstream product

• 273-13-2 benzo[1,2,5]thiadiazole 
• 85122-38-9 1,2,5-thiadiazole-3,4-dicarbaldehyde 
• 23347-22-0 3,4-dicyano-1,2,5-thiadiazole 

Downstream Products

• 13368-86-0 1,2,5-thiadiazole-3-carboxylic acid 

Relevant academic research and scientific papers

Method for preparing 1,2,3-thiadiazole-4-carboxylic acid

The invention relates to a method for preparing 1,2,3-thiadiazole-4-carboxylic acid, which comprises: preparing 4,5-dicyano-1,2,3-thiadiazole by reaction between diaminomaleonitrile and dichloroethane; preparing 1,2,3-thiadiazole 4,5-dicarboxylic acid by the cyan-hydrolysis of 4,5-dicyano-1,2,3-thiadiazole; and preparing 1,2,3-thiadiazole-4-carboxylic acid by the decarboxylation reaction of 1,2,3-thiadiazole 4,5-dicarboxylic acid. The provided process route is high in synthesis rate of the target product, moreover, the process route can be magnified, the raw materials can be easily obtained and are cheap, and industrial production can be carried out.

Topological modulation of metal-thiadiazole dicarboxylate coordination polymers through auxiliary ligand alteration

Five new CoII/ZnII coordination polymers (CPs), namely [Co(tdzdc)(4,4′-bipy)(H2O)]n (1), {[Co(tdzdc)(bpp)(H2O)]·3H2O}n (2), {[Zn2(tdzdc)2(4,4′-bipy)(H2O)2]·3H2O}n (3), [Zn2(tdzdc)2(obpy)(H2O)2]n (4) and [Zn(tdzdc)(tmb)]n (5), have been synthesized based on the primary ligand 1,2,5-thiadiazole-3,4-dicarboxylic acid (H2tdzdc) together with four selected N/O-donor auxiliary ligands, i.e., 4,4′-bipy: 4,4′-bipyridine, bpp: 1,3-bi(pyridin-4-yl)propane, obpy: [4,4′-bipyridine]-N,N′-dioxide, and tmb: 1,4-bis((1H-1,2,4-triazol-1-yl)methyl)benzene. Single-crystal structural analyses unveil different topologies and interpenetration degrees of 1-5, associated with four different kinds of coordination modes of H2tdzdc that depend on the auxiliary ligands used. CPs 1-4 are all constructed by extending the one-dimensional metal-ligand chain through the respective auxiliary ligands. Among them, the linear rigid auxiliary ligands (i.e., bipy and obpy) generate two-dimensional planes of 1, 3 and 4, which exhibit different interpenetration degrees of 0, 2 and 3, respectively, while the flexible bpp auxiliary ligand forms a three-dimensional net of 2. In contrast, CP 5 has a basic structural unit comprising dinuclear metal clusters that facilitate the formation of a 3-fold interpenetrated two-dimensional net extended through the tmb auxiliary ligand. Furthermore, magnetic investigations of the two CoII-based CPs reveal that despite being mediated by syn-anti bridging of the carboxylate, both 1 and 2 display antiferromagnetic and canted antiferromagnetic behaviors, respectively.

Organic Heterocyclothiazenes. Part 5. Cycloaddition Reactions of Tetrasulphur Tetranitride with Highly Electron Deficient Alkynes

In contrast with previous, complex, S4N4-alkyne reactions, treatment of butynedinitrile and S4N4 is found to give 1,3,5,2,4-trithiadiazepine-6,7-dicarbonitrile (8) and 1,2,5-thiadiazole-3,4-dicarbonitrile (9) very cleanly and in high yield.Hexafluorobut-2