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1336804-35-3

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1336804-35-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1336804-35-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,6,8,0 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1336804-35:
(9*1)+(8*3)+(7*3)+(6*6)+(5*8)+(4*0)+(3*4)+(2*3)+(1*5)=153
153 % 10 = 3
So 1336804-35-3 is a valid CAS Registry Number.

1336804-35-3Downstream Products

1336804-35-3Relevant articles and documents

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors

Andreani, Aldo,Granaiola, Massimiliano,Leoni, Alberto,Locatelli, Alessandra,Morigi, Rita,Rambaldi, Mirella,Varoli, Lucilla,Lannigan, Deborah,Smith, Jeff,Scudiero, Dominic,Kondapaka, Sudhir,Shoemaker, Robert H.

, p. 4311 - 4323 (2011)

The activity of a series of imidazo[2,1-b]thiazole guanylhydrazones as inhibitors of p90 ribosomal S6 kinase 2 (RSK2) is described. It was found that a small subset of compounds show both potent inhibition of RSK2 kinase activity and tumor cell growth in vitro. Detailed study of one of the most active compounds indicates a high degree of selectivity for inhibition of RSK2 compared to a spectrum of other related kinases. Selective inhibition of the MCF-7 breast tumor cell line compared to MCF-10A non-transformed cells, as well as selective inhibition of the biomarker GSK3 provides evidence that the compounds can affect the RSK2 target in cells.

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