1336804-72-8

Basic information

• Product Name: NSC 745255
• CAS NO: 1336804-72-8
• Molecular Weight: 475.915
• Mol File: 1336804-72-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: NSC 745255(CAS DataBase Reference)
• NIST Chemistry Reference: NSC 745255(1336804-72-8)
• EPA Substance Registry System: NSC 745255(1336804-72-8)

Safety Data

• Hazardous Substances Data: 1336804-72-8(Hazardous Substances Data)

Upstream product

• 851531-99-2 2-bromo-1-(2,5-dimethoxy-4-nitrophenyl)ethan-1-one 
• 1336804-44-4 C₁₈H₁₃N₃O₅S 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 1336804-70-6 C₁₇H₁₃N₃O₄S 
• 136-95-8 2-aminobenzothiazole 

Relevant articles and documents

Imidazo[2,1-b]thiazole guanylhydrazones as RSK2 inhibitors

The activity of a series of imidazo[2,1-b]thiazole guanylhydrazones as inhibitors of p90 ribosomal S6 kinase 2 (RSK2) is described. It was found that a small subset of compounds show both potent inhibition of RSK2 kinase activity and tumor cell growth in vitro. Detailed study of one of the most active compounds indicates a high degree of selectivity for inhibition of RSK2 compared to a spectrum of other related kinases. Selective inhibition of the MCF-7 breast tumor cell line compared to MCF-10A non-transformed cells, as well as selective inhibition of the biomarker GSK3 provides evidence that the compounds can affect the RSK2 target in cells.