1336873-98-3Relevant academic research and scientific papers
Copper and palladium co-catalyzed highly regio-selective 1,2-hydroarylation of terminal 1,3-dienes
Zhang, Rumeng,Li, Qifan,Zhang, Min,Chai, Sida,Duan, Yuqi,Su, Jingfei,Zhao, Qian,Zhang, Chun
, p. 13551 - 13554 (2020/11/17)
A practical copper and palladium co-catalyzed highly regio-selective hydroarylation of terminal 1,3-dienes has been developed. This chemistry afforded the terminal alkenyl group containing products, which are a kind of versatile precursor for organic synthesis, from 1,3-dienes by a practical one-step reaction. With good functional group tolerance, this protocol could be used to make a series of bio-active compounds using readily accessible starting materials. The mechanism of this reaction was explored by control experiments and kinetics studies. This journal is
Compounds and methods for treating cancer by inhibiting the urokinase receptor
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, (2017/09/15)
Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell growth, cell adhesion, angiogenesis, cancer cell invasion, apoptosis, tumor formation, tumor progression, metastasis, degradation of the extracellular matrix, pericellular proteolysis, activation of plasminogen, changes in the levels of an extracellular protease, and changes in the levels of a VEGF receptor.
COMPOUNDS AND METHODS FOR TREATING CANCER BY INHIBITING THE UROKINASE RECEPTOR
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Page/Page column 70; 76; 77, (2013/03/26)
Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell growth, cell adhesion, angiogenesis, cancer cell invasion, apoptosis, tumor formation, tumor progression, metastasis, degradation of the extracellular matrix, pericellular proteolysis, activation of plasminogen, changes in the levels of an extracellular protease, and changes in the levels of a VEGF receptor.
Virtual screening targeting the urokinase receptor, biochemical and cell-based studies, synthesis, pharmacokinetic characterization, and effect on breast tumor metastasis
Wang, Fang,Li, Jing,Sinn, Anthony L.,Knabe, W. Eric,Khanna, May,Jo, Inha,Silver, Jayne M.,Oh, Kyungsoo,Li, Liwei,Sandusky, George E.,Sledge, George W.,Nakshatri, Harikrishna,Jones, David R.,Pollok, Karen E.,Meroueh, Samy O.
, p. 7193 - 7205 (2012/01/02)
Virtual screening targeting the urokinase receptor (uPAR) led to (±)-3-(benzo[d][1,3]dioxol-5-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl) -4-phenylbutan-1-amine 1 (IPR-1) and N-(3,5-dimethylphenyl)-1-(4- isopropylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbox
