1336892-00-2Relevant academic research and scientific papers
PEDERIN AND PSYMBERIN AGENTS
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Page/Page column 42-45, (2013/03/26)
Compounds that include a pederin, psymberin or pederin/psymberin chimera scaffold. The pederin scaffold includes a substituent at the C10 and/or C13 position that may include a linker that may be conjugated to a targeting moiety. The psymberin scaffold in
Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs
Wan, Shuangyi,Wu, Fanghui,Rech, Jason C.,Green, Michael E.,Balachandran, Raghavan,Horne, W. Seth,Day, Billy W.,Floreancig, Paul E.
, p. 16668 - 16679 (2011/12/14)
The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linkages.
