133728-85-5Relevant academic research and scientific papers
(2-Acetoxyphenoxy)ethyl (APOe) as a phosphate protecting group in solid-phase synthesis of oligonucleotides via the phosphoramidite approach
Cheruvallath, Zacharia S.,Eleuteri, Alessandra,Turney, Brett,Ravikumar, Vasulinga T.
, p. 251 - 256 (2006)
The (2-Acetoxyphenoxy)ethyl (APOe) group could be an alternative to the conventional 2-cyanoethyl group for phosphate protection in solid-phase oligonucleotide synthesis to circumvent DNA alkylation by acrylonitrile generated under basic condition. This g
Efficient synthesis of deoxyribonucleoside phosphoramidites by eliminating the use of additional activator
Eleuteri, Alessandra,Capaldi, Daniel C.,Cole, Douglas L.,Ravikumar, Vasulinga T.
, p. 1879 - 1882 (1999)
An efficient, safe and cost effective synthesis of deoxyribonucleoside phosphoramidites is described. The amine hydrochloride produced as a by- product during the synthesis of nucleoside phosphorbisamidite is used as an internal activator in the synthesis
Method of preparing phosphoramidites
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Example 5, (2008/06/13)
Improved methods for preparation of phosphoramidite compounds are disclosed. The phosphoramidites are useful, for example, for the preparation of oligonucleotides by solid state oligonucleotide synthetic regimes.
