133729-81-4

Upstream product

• 35086-79-4 cinnamoyl chloride 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 

Downstream Products

• 133730-01-5 (4S)-<(3-(4-chlorophenyl)-4-phenyl)butanoyl>-4-phenylmethyl-1,3-oxazolidin-2-one 
• 133729-98-3 (S)-4-Benzyl-3-[(S)-3-(4-chloro-phenyl)-butyryl]-oxazolidin-2-one 
• 133729-99-4 (S)-4-Benzyl-3-[(R)-3-(4-chloro-phenyl)-butyryl]-oxazolidin-2-one 
• 133729-90-5 (S)-4-Benzyl-3-[(S)-3-(4-chloro-phenyl)-pentanoyl]-oxazolidin-2-one 
• 133729-91-6 (S)-4-Benzyl-3-[(R)-3-(4-chloro-phenyl)-pentanoyl]-oxazolidin-2-one 
• 1239371-89-1 (3R,4S)-methyl 1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carboxylate 
• 862283-67-8 (S)-4-benzyl-3-((3S,4R)-1-benzyl-4-(4-chlorophenyl)pyrrolidine-3-carbonyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Structure-based design of potent and selective leishmania N -myristoyltransferase inhibitors

Inhibitors of Leishmania N-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained,

Pharmaceutically active compounds

The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein and especially to selective MCR4 agonist compounds, to

2-OXAZOLIDINONES AND THEIR USE AS INHIBITORS OF ANIMAL CELL MOTILITY AND GROWTH

Cell motility and growth inhibitors, including compounds of the general structural formula (I), and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts, pro-drugs, and solvates thereof, as therapeutic agents, are disclosed.

Stereoselective Conjugate Addition of Organoaluminum Chlorides to α,β-Unsaturated Carboxylic Acid Derivatives

Organoaluminum chlorides react smoothly with α,β-unsaturated N-acyloxazolidinones providing chiral β-branched carboxylic acid derivatives.An unexpected contrast between the mode of reaction of dimethylaluminum chloride and that of the higher homologues is observed.While diethylaluminum chloride and its higher homologues react with the acceptors at low temperature via a polar pathway, dimethylaluminum chloride requires activation by UV-light or radical initiation under otherwise identical conditions.With bicyclic oxazolidinones derived from galactosamine a high stereoselection is accomplished in the formation of the branched carboxylic acid derivative.