862283-67-8Relevant academic research and scientific papers
Structure-based design of potent and selective leishmania N -myristoyltransferase inhibitors
Hutton, Jennie A.,Goncalves, Victor,Brannigan, James A.,Paape, Daniel,Wright, Megan H.,Waugh, Thomas M.,Roberts, Shirley M.,Bell, Andrew S.,Wilkinson, Anthony J.,Smith, Deborah F.,Leatherbarrow, Robin J.,Tate, Edward W.
, p. 8664 - 8670 (2015/01/09)
Inhibitors of Leishmania N-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained,
Pharmaceutically active compounds
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Page/Page column 62, (2010/02/13)
The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein and especially to selective MCR4 agonist compounds, to
