65032-81-7

Usage

General Description

5H-Pyrido(4,3-b)indole-3-carboxylic acid, 1-methyl- is a chemical compound with the molecular formula C13H11NO2. It is a derivative of the indole class of organic compounds and contains a carboxylic acid group and a methyl group. 5H-Pyrido(4,3-b)indole-3-carboxylic acid, 1-methyl- has potential applications in pharmaceutical research and drug development due to its structural characteristics and potential biological activities. It may also be used as a reagent in chemical synthesis and as a reference standard in analytical chemistry. However, further research is needed to fully understand its properties and potential uses in various industries.

InChI:InChI=1/C13H10N2O2/c1-7-12-8-4-2-3-5-9(8)15-10(12)6-11(14-7)13(16)17/h2-6,15H,1H3,(H,16,17)

Upstream product

• 143618-97-7 methyl 1-methyl-5H-pyrido<4,3-b>indole-3-carboxylate 
• 96286-19-0 ethyl 1-methyl-5H-pyrido<4,3-b>indole-3-carboxylate 
• 131334-95-7 ethyl 2-azido-3-(1-methoxymethylindol-2-yl)propenoate 
• 40899-71-6 1-benzenesulfonylindole 
• 143618-95-5 2-[(1-Benzenesulfonyl-1H-indol-2-yl)-ethoxy-methyl]-malonic acid diethyl ester 
• 143618-90-0 5-<<-2-<1-(benzenesulfonyl)indolyl>>methylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 143618-92-2 (E)-3-(1-Benzenesulfonyl-1H-indol-2-yl)-acrylic acid phenyl ester 
• 143618-88-6 methyl 3-<2-<3-<1-(hydroxyimino)ethyl>indolyl>>-2-propenoate 
• 143631-77-0 methyl 3-<2-(acetylindolyl)>-2-propenoate 
• 143618-94-4 (E)-3-(1H-indol-2-yl)acrylic acid 
• 121897-38-9 methyl (E)-3-(1H-indol-2-yl)acrylate 
• 65828-74-2 (2-Indolylmethylen)-malonsaeure 
• 65032-80-6 ethyl 1-methyl-5H-3,4-dihydropyrido<4,3-b>indole-3-carboxylate 
• 95242-11-8 C₁₂H₁₇N₂⁽¹⁺⁾*CH₃O₄S^(1-) 

Downstream Products

• 72254-58-1 Tryptophan p 2 acetate 
• 62450-07-1 3-amino-1-methyl-5H-pyrido[4,3-b]indole 

Relevant academic research and scientific papers

Iminophosphorane-Mediated Synthesis of the Genotoxic Heterocyclic Amine Trp-P-2.

A new eight-step synthesis of the genotoxic amine Trp-P-2 in an overall yield of 14.4 percent is described.The key step, formation of γ-carboline ring, involves a tandem aza Wittig/electrocyclic ring closure process.

Synthesis of Genotoxic Heterocyclic Amines Trp-P-1 and Trp-P-2

Trp-P-1 (1a) and Trp-P-2 (1b) possessing a pyridoindole system have been newly synthesized.The key reaction step in the synthetic sequence has been the thermal electrocyclic reaction of the 1-azahexa-1,3,5-triene system 3 involving the indole bond derived from 2-vinylindoles 4. 2-Vinylindole 4a has been derived from N-(benzenesulfonyl)indole (5) in a four-step sequence. 2-Vinylindole 4b has been synthesized by two routes using either ethoxymethylidene Meldrum's acid (6b) or diethyl ethoxymethylidenemalonate (10) as Michael acceptors to the 2-lithio-N-(benzenesulfonyl)indole.

Synthesis of 3-Amino-5H-pyridoindoles, Carcinogenic γ-Carbolines

The carcinogenic γ-carbolines 3-amino-1,4-dimethyl-5H-pyridoindole (1) and 3-amino-1-methyl-5H-pyridoindole (2) were synthesized efficiently by the following procedures.The key method involved the acid-catalyzed cyclization of 2-acetamido-3-(2-indolyl)alkanoic acids to 1,2-dihydro-γ-carbolines.This was followed by dehydrogenation to the γ-carbolinecarboxylates and conversion of the ester group to the carboxyl and finally to the amino one by Curtius rearrangement.Alternative methods involved the thermolysis of 4-(1-benzotriazolyl)-3,6-dimethyl-2-pyridinamine to synthesize 1 and the condensation of 3-acetylindole-2-acetonitrile with ammonia to synthesize 2.The structures of γ-carbolines 1 and 2 were unambiguously established by comparing samples of each synthesized by the two different routes.A selective and one-step synthesis of ethyl 2-acetamido-3-(2-indolyl)alkanoates was newly exploited starting from diethyl acetamidomalonate and quaternary ammonium salts of 2-indoles.