133740-48-4Relevant academic research and scientific papers
Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds
Lowe, Robert A.,Taylor, Dale,Chibale, Kelly,Nelson, Adam,Marsden, Stephen P.
, (2020/03/25)
A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxy-pyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclisation reactions of, and fusion of additional ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesised and evaluated in order to determine the biological relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries.
6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
Pei,Gupta,Badio,Padgett,Daly
, p. 2047 - 2055 (2007/10/03)
A series of tropane derivatives, related in structure to baogongteng A (1), an alkaloid from a Chinese herb, were synthesized. 6beta-Acetoxynortropane (5) had weak affinity (Ki 22 microM) for central (M1) muscarinic receptors in a [3H]quinuclidinyl benzil
Structure of the Calystegines: New alkaloids of the nortropane family
Ducrot,Lallemand
, p. 3879 - 3882 (2007/10/02)
Three new alkaloids have been isolated from Calystegia sepium; their structures have been established from their 1H and 13C N.M.R. spectra, and confirmed by the synthesis of model compounds.
