133747-63-4

Upstream product

• 133747-62-3 methyl 1-(4-fluorophenyl)-5-pyrrolidone-3-carboxylate 
• 857063-08-2 ethyl 1-(4-fluorophenyl)-5-pyrrolidone-3-carboxylate 
• 97-65-4 2-methylenesuccinic acid 
• 371-40-4 4-fluoroaniline 
• 56617-43-7 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid 

Downstream Products

• 1143521-26-9 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carbaldehyde 
• 1188542-52-0 8-{3-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]isoxazol-5-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 1188542-59-7 8-{6-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]pyridin-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 1188542-49-5 8-{4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]phenyl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione 
• 1188542-50-8 N-(6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydropyrimidin-5-yl)-4-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethoxy]benzamide 
• 1188542-16-6 3-ethyl-8-{1-[1-(4-fluorophenyl)-5-oxopyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione 
• 133747-64-5 4-[1-(4-fluorophenyl)-5-oxo-pyrrolidin-3-ylmethoxy]benzoic acid methyl ester 
• 857063-10-6 4-(bromomethyl)-1-(4-fluorophenyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

A2Badenosine receptor antagonists: Design, synthesis and biological evaluation of novel xanthine derivatives

A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like?COPD and asthma. Several potent and selective

CALCIUM RECEPTOR MODULATING AGENTS

The present invention relates generally to novel calcimimetic compounds and pharmaceutical compositions comprising them. The invention also relates to methods of treating of diseases or disorders related to the function of the calcium sensing receptor using the compounds represented in Formula I.

1-AKAN-2-OL SUBSTITUTED PIPERAZINE AND PIPERIDINE COMPOUNDS

Disclosed are novel substituted heterocyclic derivatives having the structure of Formula (I): The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermitt

Synthesis of 4-methyloxybenzoic acids and related compounds, and their inhibitory capacities toward fatty-acid and sterol biosynthesis

The synthesis of a series of 4-methyloxybenzoic acids and related compounds, and their evaluation for inhibitory capacity toward fatty-acid and sterol biosyntheses using rats' liver slices in vitro and rabbits

Phenylcarboxylic acid derivatives having hetero ring

Phenylcarboxylic acid derivatives having a hetero ring in the substituent of the formula: STR1 wherein R1 is halogen, alkyl, cycloalkyl, hydroxy, alkoxy, phenoxy which has a substituent selected from halogen and alkyl, carboxyl, alkylsulfonyloxy, phenylsulfonyloxy optionally substituted by halogen, alkylsulfonyloxyalkoxy, amino, alkanoylamino, benzoylamino, alkenyloxy, phenylalkoxyalkoxy, hydroxyalkoxy, phenylalkoxy having optionally 1 to 3 substituents selected from halogen, alkyl and alkoxy, halogenoalkyl, cycloalkyloxy optionally substituted by hydroxy, alkoxy substituted by cycloalkyl having optionally hydroxy substituent, imidazolylalkyl or imidazolylalkoxy; k is 0 or 1 to 3; or (R1)k is alkylenedioxy; A is alkylene or alkylenoxy; l is 0 or 1; B is methylene or carbonyl; m is 0 or 1; D is alkylene; E is alkylene or alkenylene; n is 0 or 1; and R2 is hydrogen or alkyl, or a salt thereof, which have fatty acid synthesis-inhibitory activity, cholesterol synthesis-inhibitory activity and are useful as antilipidemic agent, prophylactic and treating agent of arteriosclerosis, prophylactic and treating agent of obesity, antidiabetics.