13376-27-7

Upstream product

• 108-94-1 cyclohexanone 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 13376-26-6 1-cyclohex-1-enyl-2-trifluoromethylbenzene 

Downstream Products

• 1449291-53-5 4-bromo-1-cyclohexyl-2-trifluoromethylbenzene 
• 916806-97-8 4-cyclohexyl-3-(trifluoromethyl)benzoic acid 
• 957205-23-1 [4-cyclohexyl-3-(trifluoromethyl)phenyl]methanol 
• 800381-60-6 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene 
• 1418144-65-6 N-(4-cyclohexyl-3-trifluoromethylbenzyloxy)acetimidic acid ethyl ester 
• 1418144-66-7 (E)-1-(3-ethyl-4-(hydroxymethyl)phenyl)ethan-1-one-O-(4-cyclohexyl-3-(trifluoromethyl)benzyl)-oxime 
• 1230487-01-0 4-[(1E)-1-([[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino)ethyl]-2-ethylbenzaldehyde 
• 1230487-00-9 Siponimod 

Relevant academic research and scientific papers

METHOD OF PRODUCING CYCLOALKYL(TRIFLUOROMETHYL)BENZENE

An industrially excellent production method for cycloalkyl(trifluoromethyl)benzene is free of complicated steps, small in the number of steps, and high in production efficiency. Cycloalkyl(trifluoromethyl)benzene is produced by reacting a halogen-substituted trifluoromethyl benzene with magnesium metal to produce a Grignard reagent and cross-coupling the Grignard reagent with a cycloalkyl halide in the presence of an iron salt or a cobalt salt at a reaction temperature of 60° C. to 80° C.

PROCESS FOR PREPARING N-(4-CYCLOHEXYL-3-TRIFLUOROMETHYL-BENZYLOXY)-ACETIMIDIC ACID ETHYL ESTER

This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I and other intermediates that are used in such processes.