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Usage

Uses

Used in Pharmaceutical Industry:
Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)- serves as an intermediate in the production of pesticides and other agrochemicals, enhancing the effectiveness of these products in managing pests and diseases in agriculture.
Used in Materials Science:
Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)is also utilized in materials science as an intermediate for creating advanced materials with unique properties, such as polymers with specific characteristics for various applications.
Used as a Reagent in Organic Chemistry:
Furthermore, Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)- functions as a reagent in organic chemistry reactions, facilitating the synthesis of other organic compounds through its reactive bromine and trifluoromethyl groups.
It is crucial to handle Benzene, 4-(bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)with care, as it is toxic and can pose health risks upon exposure. Proper safety measures should be implemented during its use in laboratories and industrial settings.

Upstream product

• 957202-29-8 methyl 4-cyclohexyl-3-(trifluoromethyl)benzoate 
• 108-94-1 cyclohexanone 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 13376-26-6 1-cyclohex-1-enyl-2-trifluoromethylbenzene 
• 1449293-48-4 1-cyclohexyl-4-methyl-2-trifluoromethylbenzene 
• 1449293-47-3 1-cyclohex-1-enyl-4-methyl-2-trifluoromethylbenzene 
• 261952-20-9 1-bromo-4-methyl-2-(trifluoromethyl)benzene 
• 1034188-31-2 2-(trifluoromethyl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid 
• 89490-05-1 cyclohex-1-enylboronic acid 
• 161622-14-6 4-bromo-3-(trifluoromethyl)benzoic acid 
• 957205-23-1 [4-cyclohexyl-3-(trifluoromethyl)phenyl]methanol 
• 916806-97-8 4-cyclohexyl-3-(trifluoromethyl)benzoic acid 
• 1449291-53-5 4-bromo-1-cyclohexyl-2-trifluoromethylbenzene 
• 13376-27-7 1-cyclohexyl-2-(trifluoromethyl)benzene 

Downstream Products

• 1418144-66-7 (E)-1-(3-ethyl-4-(hydroxymethyl)phenyl)ethan-1-one-O-(4-cyclohexyl-3-(trifluoromethyl)benzyl)-oxime 
• 1230487-01-0 4-[(1E)-1-([[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]imino)ethyl]-2-ethylbenzaldehyde 
• 1230487-00-9 Siponimod 
• 1418144-65-6 N-(4-cyclohexyl-3-trifluoromethylbenzyloxy)acetimidic acid ethyl ester 

Relevant academic research and scientific papers

AROMATIC RING DERIVATIVE AS IMMUNOREGULATION AND PREPARATION METHOD AND APPLICATION OF AROMATIC RING DERIVATIVE

Relating to a compound represented by formula (I) and a pharmaceutically acceptable salt of the compound, and an application of the compound as an S1P1 agonist.

PROCESS FOR MAKING SIPONIMOD AND INTERMEDIATE THEREOF

The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates.

PROCESS FOR PREPARATION OF SIPONIMOD, ITS SALTS AND SOLID STATE FORMS THEREOF

The present application provides process for preparation of siponimod, intermediates of siponimod, salts of siponimod, polymorphic forms and solid dispersions of siponimod and its salts thereof. The present application specifically provides crystalline polymorphic forms of siponimod base, siponimod hemifumarate and other salts and pharmaceutical compositions thereof. Also provided are solid dispersions of siponimod hemifumarate and pharmaceutical compositions containing them.

AZETIDINE MODULATORS OF THE SPHINGOSINE 1-PHOSPHATE RECEPTOR

Described are deuterium-substituted azetidine compounds of Formula (I), which are modulators of sphingosine 1 -phosphate receptor. Also described are pharmaceutical compositions comprising the deuterium-substituted azetidine compounds, and methods of use thereof.

PROCESS FOR PREPARING N-(4-CYCLOHEXYL-3-TRIFLUOROMETHYL-BENZYLOXY)-ACETIMIDIC ACID ETHYL ESTER

This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I and other intermediates that are used in such processes.