1337862-57-3

Upstream product

• 1142-20-7 N-Cbz-Ala 
• 1730-25-2 allylmagnesium bromide 
• 2622-05-1 allylmagnesium bromide 
• 114744-83-1 (S)-benzyl (1-(N,O-dimethylhydroxylamine)-1-oxopropan-2-yl)carbamate 

Downstream Products

• 127041-68-3 (2S,3SR)-2-{[(benzyloxy)carbonyl]amino}hex-5-en-3-ol 
• 127041-69-4 benzyl (2S,3R)-3-hydroxyhex-5-en-2-ylcarbamate 
• 1337862-63-1 benzyl (2S,3R)-3-(tert-butyldimethylsilyloxy)hex-5-en-2-ylcarbamate 
• 1337862-70-0 (2S,3R)-benzyl 3-(tert-butyldimethylsilyloxy)-2-methyl-5-oxopyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

A facile approach to trans-4,5-pyrrolidine lactam and application in the synthesis of nemonapride and streptopyrrolidine

An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four s

A practical route to enantiopure 3-hydroxy-pyrrolidines: application to a straightforward synthesis of (-)-bulgecinine

A practical synthesis of enantiopure substituted 3-hydroxy-pyrrolidines is reported. In four steps, starting from commercially available amino acids as chiral educts, this method allows for an efficient preparation of a variety of 3-hydroxy-pyrrolidines, as well as 3-hydroxy-piperidines and azepanes. Application of this methodology for a straightforward asymmetric synthesis of (-)-bulgecinine is also described.