114744-83-1

Basic information

• Product Name: (2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: TERT-BUTYL (2-OXO-2-PHENYLETHYL)CARBAMATE;TERT-BUTYL N-(2-OXO-2-PHENYLETHYL)CARBAMATE;CarbaMic acid, N-[(1S)-2-(MethoxyMethylaMino)-1-Methyl-2-oxoethyl]-, phenylMethyl ester;Benzyl [(2S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl]carbamate
• CAS NO: 114744-83-1
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.29
• Mol File: 114744-83-1.mol
• Article Data: 33

Chemical Properties

• Melting Point: 87-89 °C
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• PKA: 10.98±0.46(Predicted)
• CAS DataBase Reference: (2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(114744-83-1)
• EPA Substance Registry System: (2-OXO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(114744-83-1)

Safety Data

• Hazardous Substances Data: 114744-83-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Canadian Journal of Chemistry, 69, p. 2059, 1991 DOI: 10.1139/v91-298

Upstream product

• 1142-20-7 N-Cbz-Ala 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 79-22-1 methyl chloroformate 
• 65638-93-9 N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid 
• 501-53-1 benzyl chloroformate 
• 99790-15-5 ((S)-2-Imidazol-1-yl-1-methyl-2-oxo-ethyl)-carbamic acid benzyl ester 

Downstream Products

• 114744-86-4 ((S)-1-Methyl-2-oxo-butyl)-carbamic acid benzyl ester 
• 82353-55-7 benzyl (S)-1-oxopropan-2-ylcarbamate 
• 54064-02-7 benzyl [(1S)-1-methyl-2-oxo-2-phenylethyl]carbamate 
• 120589-26-6 (S)-N-Cbz-4-amino-1-phenyl-1-pentyn-3-one 
• 198956-41-1 ((2S)-1-cyano-1-hydroxypropan-2-yl)carbamic acid benzyl ester 
• 198955-63-4 (2S)-2-(benzyloxycarbonylamino)-1-(6-methylbenzo[d][1,3]oxazol-2-yl)-1-propanol 
• 198955-62-3 (2S)-2-(benzyloxycarbonylamino)-1-(5-methylbenzo[d][1,3]oxazol-2-yl)-1-propanol 
• 198955-59-8 (2S)-2-(benzyloxycarbonylamino)-1-benzo[d][1,3]oxazol-2-yl-1-propanol 
• 198955-64-5 (2S)-2-(benzyloxycarbonylamino)-1-(7-methylbenzo[d][1,3]oxazol-2-yl)-1-propanol 
• 198955-61-2 (2S)-2-(benzyloxycarbonylamino)-1-(4-methylbenzo[d][1,3]oxazol-2-yl)-1-propanol 
• 198955-60-1 (2S)-2-(benzyloxycarbonylamino)-1-(oxazolo[4,5,b]pyridin-2-yl)-1-propanol 
• 871917-79-2 benzyl {(1S)-2-[3,5-bis(trifluoromethyl)phenyl]-1-methyl-2-oxoethyl}carbamate 
• 1092969-77-1 (S)-1-(benzyloxycarbonylamino)ethyl 3,4,5-tris(dodecanoxy)phenyl ketone 

Relevant articles and documents

Efficient preparation of stereopure amphiphilic 1,2-amino alcohols by using preparative enantioselective HPLC

Chiral amphiphiles are useful for controlling the structures and properties of supramolecular assemblies, but their stereocontrolled synthesis is generally difficult, because their long alkyl chains tend to bring unfavorable effects on the solubility, rea

Probing α-Amino Aldehydes as Weakly Acidic Pronucleophiles: Direct Access to Quaternary α-Amino Aldehydes by an Enantioselective Michael Addition Catalyzed by Br?nsted Bases

The high tendency of α-amino aldehydes to undergo 1,2-additions and their relatively low stability under basic conditions have largely prevented their use as pronucleophiles in the realm of asymmetric catalysis, particularly for the production of quaternary α-amino aldehydes. Herein, it is demonstrated that the chemistry of α-amino aldehydes may be expanded beyond these limits by documenting the first direct α-alkylation of α-branched α-amino aldehydes with nitroolefins. The reaction produces densely functionalized products bearing up to two, quaternary and tertiary, vicinal stereocenters with high diastereo- and enantioselectivity. DFT modeling leads to the proposal that intramolecular hydrogen bonding between the NH group and the carbonyl oxygen atom in the starting α-amino aldehyde is key for reaction stereocontrol.

Difluromethyl-substituted oxazolidinone compounds and application thereof

The invention relates to difluromethyl-substituted oxazolidinone compounds and application thereof, especially the application of the compounds as drugs for treatment and prevention of cardiovascular diseases. To be specific, the invention relates to the compounds shown in a general formula (I) or the enantiomers, diastereoisomers, hydrates, solvates or pharmaceutically acceptable salts of the compounds, wherein each variable is defined as in the specification. The invention further relates to the compounds shown in the general formula (I) or (Ia) or the application of the enantiomers, diastereoisomers, hydrates, solvates or pharmaceutically acceptable salts or pharmaceutical compositions of the compounds, especially the application in inhibiting CETP. Please the formula in the specification.