1337880-36-0

Basic information

• Product Name: 3-Chloro-6-cyanoisoquinoline, 3-Chloro-6-cyano-2-azanaphthalene
• Synonyms: 3-Chloro-6-cyanoisoquinoline, 3-Chloro-6-cyano-2-azanaphthalene;3-Chloroisoquinoline-6-carbonitrile;3-Chloro-6-isoquinolinecarbonitrile
• CAS NO: 1337880-36-0
• Molecular Formula: C10H5ClN2
• Molecular Weight: 188.6131
• Mol File: 1337880-36-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Chloro-6-cyanoisoquinoline, 3-Chloro-6-cyano-2-azanaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-6-cyanoisoquinoline, 3-Chloro-6-cyano-2-azanaphthalene(1337880-36-0)
• EPA Substance Registry System: 3-Chloro-6-cyanoisoquinoline, 3-Chloro-6-cyano-2-azanaphthalene(1337880-36-0)

Safety Data

• Hazardous Substances Data: 1337880-36-0(Hazardous Substances Data)

Upstream product

• 891785-28-7 6-bromo-isoquinolin-3-ylamine 

Relevant articles and documents

Novel Compounds

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of conditions involving mitochondrial dysfunction and cancer. Compounds of the invention include compounds having the formula (I): (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f, R1g, R2, X, L and A are as defined herein.