891785-28-7

Basic information

• Product Name: 6-bromoisoquinolin-3-amine
• Synonyms: 6-bromoisoquinolin-3-amine;3-Amino-6-bromoisoquinoline;6-broMo-3-isoquinolinaMine;6-Bromoisoquinolin-3-amine, 3-Amino-6-bromo-2-azanaphthalene
• CAS NO: 891785-28-7
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.08
• Product Categories: CHIRAL CHEMICALS;Building Blocks;Isoquinoline
• Mol File: 891785-28-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 387.6 °C at 760 mmHg
• Flash Point: 188.2 °C
• Appearance: /
• Density: 1.649 g/cm³
• Vapor Pressure: 3.26E-06mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.49±0.38(Predicted)
• CAS DataBase Reference: 6-bromoisoquinolin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromoisoquinolin-3-amine(891785-28-7)
• EPA Substance Registry System: 6-bromoisoquinolin-3-amine(891785-28-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 891785-28-7(Hazardous Substances Data)

Usage

Uses

6-Bromoisoquinolin-3-amine is employed in the comprehensive structure-activity relationship studies to identify the allosteric inhibitors that exhibit selective recognition of protein arginine methyltransferase PRMT3 in human cells.

InChI:InChI=1/C9H7BrN2/c10-8-2-1-6-5-12-9(11)4-7(6)3-8/h1-5H,(H2,11,12)

Upstream product

• 26177-44-6 4-bromobenzylamine hydrochloride 
• 552331-06-3 6-bromo-3-chloro-isoquinoline 
• 956100-48-4 N-(4-bromo-benzyl)-2,2-diethoxy-acetamidine 
• 934343-53-0 benzyl-(6-bromo-isoquinolin-3-yl)-amine 
• 925672-85-1 1,6-dibromoisoquinolin-3-amine 

Downstream Products

• 891785-30-1 6-bromo-3-fluoro-isoquinoline 
• 1337880-36-0 3-chloroisoquinoline-6-carbonitrile 

Relevant articles and documents

4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES

[00397] This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.

Isoquinolin-3-Ylurea Derivatives

The invention relates to isoquinolin-3-ylurea derivatives of formula (I) wherein R1 represents (C1-C3)alkyl, (C1-C3)haloalkyl or cyclopropyl, R4 represents H and the substituents R2 and R3 and R5 have the meanings disclosed in the specification; and to the salts of such compounds. These compounds are useful for the prevention or the treatment of bacterial infections.

THIADIAZOLE MODULATORS OF PKB

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the th