13379-82-3Relevant academic research and scientific papers
A novel route to synthesis of flavones from salicylaldehyde and acetophenone derivatives
Sashidhara, Koneni V.,Kumar, Manoj,Kumar, Abdhesh
, p. 2355 - 2359 (2012)
Convenient, facile, and alternate synthesis of medicinally important flavones is reported. The 2-hydroxychalcones derived from condensation between acetophenones and salicylaldehyde, underwent oxidative cyclization on heating in the presence of catalytic iodine, generating diversified flavones under solvent-free conditions. Eleven compounds have been synthesized in good to excellent yields and their mechanism of formation is described.
Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted
Batovska, Daniela,Parushev, Stoyan,Stamboliyska, Bistra,Tsvetkova, Iva,Ninova, Mariana,Najdenski, Hristo
experimental part, p. 2211 - 2218 (2009/09/30)
A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4′-chloro or 3′,4′,5′-trimethoxy groups. Their other ring B was variously substituted. It was found that the anti-staphylococcal activity of chalcones was related to the energy difference between the two highest occupied molecular orbitals (HOMO and HOMO-1). Presence of hydroxyl group in ring B was not a determinant factor for the anti-staphylococcal activity, but the lipophilicity of ring A of the hydroxyl chalcones was of importance.
