1337981-75-5

Upstream product

• 197899-19-7 (2R)-1-chloro-2-hydroxy-4-pentene 
• 181272-46-8 (2R)-1-cyano-2-hydroxy-4-pentene 
• 121772-40-5 (R)-ethyl 3-hydroxyhex-5-enoate 
• 1337981-71-1 C₁₅H₁₈O₄ 
• 1337981-73-3 C₁₅H₁₉BrO₅ 

Downstream Products

• 1337981-68-6 C₃₃H₃₁O₅P 

Relevant academic research and scientific papers

ROSUVASTATIN CALCIUM INTERMEDIATE AND PREPARATION METHOD THEREOF

A rosuvastatin calcium intermediate as shown by Formula I is prepared as follow: a) subjecting chloroethylene, magnesium and R-epoxy chloropropane to Grignard reaction, b) adding sodium cyanide for nucleophilic substitution reaction, c) adding alcohol for alcoholysis reaction, d) adding alkaline solvent for hydroxyl protection, e) subjecting the mixture to oxidation reaction, f) adding triphenyl phosphorus and subjecting to Wittig reaction in the presence of alkali to obtain the compound of formula I. The method has moderate reaction conditions, is convenient and stable and can be applied to industrial production.

ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME

A method for preparing a rosuvastatin calcium intermediate, including a) contacting a halogenated ethene with magnesium metal to obtain a halogenated ethene Grignard reagent, and carrying out a Grignard reaction between the halogenated ethene Grignard reagent and R-epichlorohydrin; b) adding sodium cyanide for carrying out a nucleophilic substitution reaction; c) adding alcohol for carrying out an alcoholysis reaction; d) adding a basic solvent for carrying out protection of a first hydroxyl group; e) selectively oxidizing a second hydroxyl group; and f) adding triphenylphosphine in alkaline condition for carrying out a Wittig reaction.