133804-66-7Relevant articles and documents
BACTERIAL EFFLUX PUMP INHIBITORS
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Paragraph 0163, (2016/10/11)
Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.
INHIBITORS OF STEAROYL-COA DESATURASE
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, (2009/06/27)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
Bis- and oligo(trifluoromethyl)benzenes: Hydrogen/metal exchange rates and gas-phase acidities
Schlosser, Manfred,Mongin,Porwisiak, Jacek,Dmowski, Wojciech,Bueker, Heinz H.,Nibbering, Nico M. M.
, p. 1281 - 1286 (2007/10/03)
The proton mobilities (kinetic acidities) of bis- and tris(trifluoromethyl)benzene are dictated to a large extent by steric factors; the trifluoromethyl group is a fairly bulky substituent that can seriously impede the approach of the metalating reagent. Most Satisfactory results in terms of yields and selectivities have been achieved with lithium 2,2,6,6-tetramethylpiperidide or with methyllithium in the presence of potassium tert-butoxide, a slim version of the standard superbase. The rates of deprotonation under irreversible conditions do not parallel the thermodynamic (equilibrium) acidities. Substituent effects on the deprotonation energies in the gas phase appear to be additive: each trifluoromethyl group lowers it by 13 kcal mol-1 when located ortho with respect to the carbanion, and by 10 kcal mol-1 when located in a meta or para position.
