133810-09-0

Basic information

• Product Name: (RS:3RS)-2-chloro-3-methoxy-3-phenyl-propionic acid
• CAS NO: 133810-09-0
• Molecular Weight: 214.649
• Mol File: 133810-09-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS:3RS)-2-chloro-3-methoxy-3-phenyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (RS:3RS)-2-chloro-3-methoxy-3-phenyl-propionic acid(133810-09-0)
• EPA Substance Registry System: (RS:3RS)-2-chloro-3-methoxy-3-phenyl-propionic acid(133810-09-0)

Safety Data

• Hazardous Substances Data: 133810-09-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 621-82-9 Cinnamic acid 
• 14371-10-9 (E)-3-phenylpropenal 
• 858783-10-5 2-chloro-3-methoxy-3-phenyl-propionaldehyde 
• 140-10-3 (E)-3-phenylacrylic acid 
• 507-40-4 tert-butylhypochlorite 

Relevant articles and documents

The vicinal functionalization of olefins: A facile route to the direct synthesis of β-chlorohydrins and β-chloroethers

An efficient and environmentally benign protocol for the synthesis of vicinal chlorohydroxy and chloromethoxy derivatives in a highly regioselective manner from olefins using NH4Cl as a chlorine source and oxone as an oxidant in aqueous acetone and methanol is demonstrated. This methodology offers an additive and metal chloride free approach and is endowed with simple reaction conditions, high yields a broad substrate scope and good functional group tolerance. Moreover, the aromatic substrates with a terminal double bond exhibited merely Markovnikov selectivity, while the internal alkenes show exclusive regiocontrol and low to moderate diastereoselectivity.