133813-44-2

Upstream product

• 82110-21-2 (S)-2-methyl-3,4,5,6-tetrahydro-2H-pyran-4-one 
• 82110-13-2 (2S,4S)-4-hydroxy-2-methyl-3,4,5,6-tetrahydro-2H-pyran 
• 133813-41-9 (2S,4S)-2,4-dihydroxyhept-6-ene 
• 81076-06-4 (2S,3R,4S)-(-)-2,3-Epoxy-6-hepten-4-ol 
• 24581-03-1 (5E)-hepta-1,5-dien-4-ol 
• 146565-11-9 (2S,4R)-4-(3-Benzyloxy-5-fluoro-phenyl)-2-methyl-tetrahydro-pyran-4-ol 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

HETEROCYCLES FOR USE AS INHIBITORS OF LEUKOTRIENES

The invention concerns a heterocycle of the formula I wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R 1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R 2 and R 3 together form a group of the formula --A 2 --X 2 --A 3 -- which, together with the carbon atom to which A 2 and A 3 are attached, defines a ring having 4 to 7 ring atoms, wherein A 2 and A 3, which may be the same or different, each is (1-4C)alkylene and X 2 is oxy, thio, sulphinyl, sulphonyl or imino; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.