82110-13-2Relevant articles and documents
CYCLIC SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES
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Page/Page column 48, (2018/09/28)
The present invention provides novel cyclic substituted imidazo[4,5- c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R5, R6, X and Z are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
Utilizing on- and off-line monitoring tools to follow a kinetic resolution step during flow synthesis
Farley, Kathleen A.,Reilly, Usa,Anderson, Dennis P.,Boscoe, Brian P.,Bundesmann, Mark W.,Foley, David A.,Lall, Manjinder S.,Li, Chao,Reese, Matthew R.,Yan, Jiangli
, p. 348 - 354 (2017/03/16)
In situ reaction monitoring tools offer the ability to track the progress of a synthetic reaction in real time to facilitate reaction optimization and provide kinetic/mechanistic insight. Herein, we report the utilization of flow NMR, flow IR, and other off-line spectroscopy tools to monitor the progress of a flow chemistry reaction. The on-line and off-line tools were selected to facilitate the stereoselective kinetic resolution of a key racemic monomer, which lacked a chromophore, making conventional reaction monitoring difficult. Copyright
4-Methoxy-2-methyltetrahydropyrans: Chiral Leukotriene Biosynthesis Inhibitors, Related to ICI D2138, Which Display Enantioselectivity
Crawley, Graham C.,Briggs, Malcolm T.,Dowell, Robert I.,Edwards, Philip N.,Hamilton, Patricia M.,et al.
, p. 295 - 296 (2007/10/02)
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