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Usage

Uses

Used in Pharmaceutical Industry:
4-(6-chloropyridin-2-yl)benzonitrile is utilized as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(6-chloropyridin-2-yl)benzonitrile serves as a key intermediate, playing a crucial role in the development of compounds that address agricultural needs, such as pest control and crop protection.
Used in Organic Chemistry Research:
4-(6-chloropyridin-2-yl)benzonitrile is employed as a building block in organic chemistry for the synthesis of more complex molecules, facilitating the exploration of new chemical pathways and the creation of novel compounds with potential applications across various fields.
Used in Drug Development:
4-(6-chloropyridin-2-yl)benzonitrile is under investigation for its potential biological activities, with researchers exploring its use in drug development to harness its properties for therapeutic purposes, pending the outcomes of ongoing studies.

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 

Relevant academic research and scientific papers

A Micellar Catalysis Strategy for Suzuki-Miyaura Cross-Couplings of 2-Pyridyl MIDA Boronates: No Copper, in Water, Very Mild Conditions

Suzuki-Miyaura (SM) cross-couplings of 2-pyridyl MIDA boronates can be successfully carried out in the complete absence of copper by attenuation of the Lewis basicity associated with the pyridyl nitrogen using selected substituents (e.g., fluorine or chlorine) on the ring. This strategy imparts additional synthetic options compared with existing approaches based on the use of Lewis acids or N-oxides. Thus, access to highly valued 2-substituted pyridyl rings via an initial Suzuki-Miyaura coupling can be followed by dehalogenation, SNAr reactions, or a second SM coupling to arrive at 2,6-disubstituted pyridyl arrays, all run in a single pot, enabled by micellar catalysis in water. Accessing targets within drug-like space is demonstrated in a four-step, one-pot sequence. Computational data suggest that the major role being played by electron-withdrawing substituents in promoting these cross-couplings without the need for copper is to slow the rates of protodeboronation of intermediate 2-pyridylboronic acids.

Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of potassium 2-pyridyl trifluoroborate with aryl (heteroaryl) halides

Palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of potassium pyridine-2-trifluoroborates and various aryl (heteroaryl) halides can generate the corresponding desired coupling products with moderate to good yields. It can be carried out under the conditions with ethanol as solvent, Pd(OAc) 2 and SPhos as catalyst system and Na2CO3 as a base.