1338214-83-7

Basic information

• Product Name: methyl 4-oxo-2-phenyl-2,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylate
• Synonyms: methyl 4-oxo-2-phenyl-2,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylate
• CAS NO: 1338214-83-7
• Molecular Weight: 320.304
• Mol File: 1338214-83-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 4-oxo-2-phenyl-2,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-oxo-2-phenyl-2,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylate(1338214-83-7)
• EPA Substance Registry System: methyl 4-oxo-2-phenyl-2,4-dihydrochromeno[4,3-c]pyrazole-3-carboxylate(1338214-83-7)

Safety Data

• Hazardous Substances Data: 1338214-83-7(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 80306-63-4 dimethyl acetylenedicarboxylate 
• 614-65-3 2-hydroxybenzaldehyde phenylhydrazone 
• 90-02-8 salicylaldehyde 
• 1338214-56-4 4-chloro-3-(methoxalyl)coumarin 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 36307-77-4 4-trimethylsilanyloxy-chromen-2-one 

Relevant articles and documents

La(OTf)3 catalyzed reaction of salicylaldehyde phenylhydrazones with β-ketoesters and activated alkynes: Facile approach for the preparation of chromenopyrazolones

A facile approach has been developed for the preparation of chromenopyrazolones (5a-o, 7a-k) by the reaction of salicylaldehyde phenylhydrazones (3a-o) with β-ketoesters (4a, 4f-g) and activated alkynes (6a-e) in the presence of La(OTf)3 with good yields. However, the reaction of salicylaldehyde phenylhydrazones (3a, 3c, 3j-k, 3n) with ethyl 4-chloro-3-oxobutanoate (4e) underwent cyclization with reductive dechlorination and provided the methyl chromenopyrazolones instead of chloromethyl chromenopyrazolones. The present solvent free protocol provided the novel heterocyclic compounds.