1338225-31-2

Basic information

• Product Name: C₁₈H₁₇N₃O
• Synonyms: C₁₈H₁₇N₃O
• CAS NO: 1338225-31-2
• Molecular Weight: 291.352
• Mol File: 1338225-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₇N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₇N₃O(1338225-31-2)
• EPA Substance Registry System: C₁₈H₁₇N₃O(1338225-31-2)

Safety Data

• Hazardous Substances Data: 1338225-31-2(Hazardous Substances Data)

Upstream product

• 1122-62-9 2-acetylpyridine 
• 1005237-42-2 C₉H₉NO₄ 
• 78831-87-5 2,4-dimethylbenzyl bromide 
• 66317-38-2 6-(pyridine-2-yl)-2,3-dihydropyridazin-3-one 

Relevant articles and documents

Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative has been found to increase EAAT2 protein levels in astrocytes. A structure-activity relationship study revealed that several components of the molecule were required for activity, such as the thioether and pyridazine. Modification of the benzylthioether resulted in several derivatives (7-13, 7-15 and 7-17) that enhanced EAAT2 levels by >6-fold at concentrations 50 of 0.5 μM.