66317-38-2

Basic information

• Product Name: 3(2H)-Pyridazinone, 6-(2-pyridinyl)-
• Synonyms: 3(2H)-Pyridazinone, 6-(2-pyridinyl)-;6-Pyridin-2-ylpyridazin-3-ol;6-PYRIDIN-2-YL-3-PYRIDAZINONE
• CAS NO: 66317-38-2
• Molecular Formula: C₉H₇N₃O
• Molecular Weight: 173.18
• Mol File: 66317-38-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(2H)-Pyridazinone, 6-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 6-(2-pyridinyl)-(66317-38-2)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 6-(2-pyridinyl)-(66317-38-2)

Safety Data

• Hazardous Substances Data: 66317-38-2(Hazardous Substances Data)

Upstream product

• 1122-62-9 2-acetylpyridine 
• 298-12-4 Glyoxilic acid 
• 160427-24-7 4-Hydroxy-6-pyridin-2-yl-4,5-dihydro-2H-pyridazin-3-one 
• 78784-69-7 6-Pyridin-2-yl-4,5-dihydro-2H-pyridazin-3-one 
• 1005036-22-5 potassium 2-hydroxy-4-oxo-4-(pyridin-2-yl)butanoate 
• 1005237-42-2 C₉H₉NO₄ 
• 1005236-94-1 3-methoxy-6-(pyridin-2-yl)-pyridazine 
• 127-68-4 sodium 3-nitrobenzenesulfonate 
• 160427-16-7 ethyl 3-(pyridin-2-yl)-4,5-dihydroisoxazole-5-carboxylate 
• 160427-20-3 2-hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester 
• 13672-79-2 methyl 4-oxo-4-(2-pyridyl)butanoate 

Downstream Products

• 1338225-29-8 C₁₇H₁₃ClFN₃O 
• 1338225-28-7 C₁₇H₁₃ClFN₃O 
• 1338225-27-6 C₁₈H₁₇N₃O 
• 1338225-26-5 C₁₆H₁₁ClFN₃O 
• 1338225-31-2 C₁₈H₁₇N₃O 
• 1338225-30-1 C₁₆H₁₁F₂N₃O 
• 892415-26-8 C₁₆H₁₂ClN₃S 
• 1338225-02-7 C₁₆H₁₁Cl₂N₃S 
• 1338225-03-8 C₁₆H₁₁Cl₂N₃S 
• 923061-34-1 C₁₆H₁₁Cl₂N₃S 
• 1338225-04-9 C₁₆H₁₁Cl₂N₃S 
• 1338225-07-2 C₁₆H₁₁F₂N₃S 
• 1338225-09-4 C₁₆H₁₀F₃N₃S 
• 893993-67-4 C₁₇H₁₅N₃S 

Relevant articles and documents

Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative has been found to increase EAAT2 protein levels in astrocytes. A structure-activity relationship study revealed that several components of the molecule were required for activity, such as the thioether and pyridazine. Modification of the benzylthioether resulted in several derivatives (7-13, 7-15 and 7-17) that enhanced EAAT2 levels by >6-fold at concentrations 50 of 0.5 μM.

LINEAR PYRIDAZINE AND PYRROLE COMPOUNDS, METHOD FOR OBTAINING THEM AND APPLICATIONS

The present invention relates to linear pyridazine compounds, and more particularly to those of these compounds which are oligopyridazine compounds, to processes for obtaining them, to their uses, and also to their reduction to pyrroles and to the uses of the pyrrole, pyridazinylpyrrole and oligopyrrole compounds obtained. The invention relates in particular to the uses as medicaments, in particular for treating pathologies such as cancer, bacterial infections or parasitic infections, and also the applications in the materials, environmental, electronics and optics field.

COUPLING OF ORGANOTIN REAGENTS WITH ARYL, ACYL AND HETEROARYL HALIDES: SYNTHESIS OF PYRIDAZINE AND QUINOXALONE DERIVATIVES

Couplin of organotin reagents Bu3SnAr (Ar = 2- or 3-thienyl, 2- or 3-pyridyl) with ClCOCH2CH2CO2Et in the presence of PdCl(CH2Ph)(PPh3)2 yields β-ketoesters ArCOCH2CH2CO2Et which were converted with hydrazine hydrate into 6-substituted 4,5-dihydropyridazin-3(2H)-ones, and thence to 3-halogeno-6-substituted pyridazines.The latter also couple under similar conditions with Bu3SnAr to yield 3-heteroarylpyridazines.With catalysts, coupling of ClCOCO2Et and Bu3SnAr proceeds with loss of carbon monoxide giving ArCO2Et, but without catalyst ArCOCO2Et is formed from which the3-heteroarylquinoxalin-3-one is prepared.The reactions of Bu3SnAr with 4-XC6H4Br (X = H,-OMe, -CN, -NO2) are also described.