1338251-74-3

Basic information

• Product Name: C₂₄H₂₆F₃N₃O₃
• CAS NO: 1338251-74-3
• Molecular Weight: 461.484
• Mol File: 1338251-74-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₆F₃N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₆F₃N₃O₃(1338251-74-3)
• EPA Substance Registry System: C₂₄H₂₆F₃N₃O₃(1338251-74-3)

Safety Data

• Hazardous Substances Data: 1338251-74-3(Hazardous Substances Data)

Upstream product

• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 1016258-66-4 1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate 
• 1338251-65-2 C₁₆H₂₁N₃O₃*ClH 
• 1338251-62-9 C₂₀H₂₇N₃O₄ 
• 1338251-61-8 C₂₀H₂₉N₃O₅ 
• 1192189-66-4 4-[(benzyloxycarbonylamino)methyl]-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 
• 247133-44-4 4-benzyloxycarbonylaminomethyl-4-ethoxycarbonylpiperidine-1-carboxylic acid tert-butyl ester 
• 1016258-69-7 1-tert-butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate 
• 1207178-51-5 C₁₂H₂₁N₃O₂ 
• 4395-98-6 4-cyanopiperidine 

Relevant articles and documents

Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers

To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 4-piperidinecarboxylate and 4-piperidinecyanide derivatives were prepared and evaluated for in vitro and in vivo activity against α1G calcium channel. Among them, several compounds showed good T-type calcium channel inhibitory activity and minimal off-target activity over hERG channel (% inhibition at 10 μM = 61.85-71.99, hERG channel IC50 = 1.57 ± 0.14-4.98 ± 0.36 μM). Selected compound 31a was evaluated on SNL model of neuropathic pain and showed inhibitory effect on mechanical allodynia.