1338320-55-0Relevant academic research and scientific papers
Synthesis, structure-activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors
Wang, Yan-Xiang,Li, Yu-Huan,Li, Ying-Hong,Gao, Rong-Mei,Wang, Hui-Qiang,Liu, Yan-Xin,Gao, Li-Mei,Lu, Qiao-Ni,Jiang, Jian-Dong,Song, Dan-Qing
, p. 5787 - 5790 (2011/10/18)
Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure-activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs synthesized, compound 7f bearing a methylenedioxy at the R4 and R5 positions afforded an anti-CVB3 activity and a reasonable selectivity index (SI = 26.8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation.
