1338544-01-6 Usage
Uses
Used in Pharmaceutical Industry:
(R)-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamic acid tert-butyl ester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. The presence of the carbamic acid moiety and the boron-containing dioxaborolane group may provide opportunities for the development of new drugs with potential biological activities.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamic acid tert-butyl ester may be utilized as a building block for the creation of novel agrochemicals, such as pesticides or herbicides, due to its unique structural features.
Used in Materials Science:
(R)-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)carbamic acid tert-butyl ester could also find applications in the field of materials science, where its structural components might be exploited to develop new materials with specific properties, such as improved stability or reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1338544-01-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,8,5,4 and 4 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1338544-01:
(9*1)+(8*3)+(7*3)+(6*8)+(5*5)+(4*4)+(3*4)+(2*0)+(1*1)=156
156 % 10 = 6
So 1338544-01-6 is a valid CAS Registry Number.
1338544-01-6Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel 1-phenyl phenanthridin-6(5H)-one derivatives as anti-tumor agents targeting TOPK
Hu, Quan-Fang,Gao, Tian-Tao,Shi, Yao-Jie,Lei, Qian,Liu, Zhi-Hao,Feng, Qiang,Chen, Zhen-Jia,Yu, Luo-Ting
, p. 407 - 422 (2018/11/24)
T–lymphokine-activated killer cell–originated protein kinase (TOPK) is a serine-threonine mitogen-activated protein kinase that is highly expressed in many types of human cancer. Due to its important role in cancer progression, TOPK is becoming an attractive target in chemotherapeutic drug design. In this study, a series of 1-phenyl phenanthridin-6(5H)-one derivatives have been identified as a novel chemical class of TOPK inhibitors. Some of them displayed very potent anti-cancer activity with IC50s less than 100 nM, superior than reference compound OTS964. The most potent compound, 9g suppressed the growth of cancer cells by apoptosis and specifically inhibited the activities of TOPK. Oral administration of 9g effectively suppressed tumor growth with TGI >79.7% in colorectal cancer xenograft models, demonstrating superior efficacy compared to OTS964. Pharmacokinetic studies reveal its good oral bioavailability. Our findings therefore show that 9g is a specific inhibitor of TOPK both in vitro and in vivo that may be further developed as a potential therapeutic agent against colorectal cancer.
