1338549-48-6

Basic information

• Product Name: (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS NO: 1338549-48-6
• Molecular Weight: 609.635
• Mol File: 1338549-48-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(1338549-48-6)
• EPA Substance Registry System: (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(1338549-48-6)

Safety Data

• Hazardous Substances Data: 1338549-48-6(Hazardous Substances Data)

Upstream product

• 141850-54-6 (2R,4R)-tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 88744-04-1 (9-fluorenyl)methyl pentafluorophenyl carbonate 
• 1338549-36-2 (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-tert-butoxycarbonylmethyoxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-28-2 (2R,4R)-4-tert-butoxycarbonylmethoxy-2-(4-tosyloxymethyl)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-27-1 (2R,4R)-4-tert-butoxycarbonylmethoxy-2-hydroxymethyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-26-0 (2R,4R)-4-tert-butoxycarbonylmethoxy-2-(tert-butyldimethylsilanyloxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design and stereoselective synthesis of four peptide nucleic acid monomers with cyclic structures in backbone

Four isomers of the monomer of peptide nucleic acid (PNA) were derived from (2S,4R)-4-hydroxyproline; they had different stereochemistries at the C 2 and C4 positions in the pyrrolidine ring. These different backbone conformations corresponding to four different stereochemistries were realized through a combination of inversions at the C2 and the C4 positions in pyrrolidine ring. The obtained backbone frameworks were reacted with N-benzoyl thymine to give the corresponding PNA monomers. Spectroscopic comparison of the resultant monomers confirmed their stereochemistries.