141850-54-6

Basic information

• Product Name: 1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE
• Synonyms: (2R,4R)-Tert-butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate;(2R,4R)-4-Hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester;tert-Butyl (2R,4R)-4-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate;N-BOC-(2R,4R)-4-hydroxy-2-(hydroxyMethyl)pyrrolidine;(4R)-1-Boc-4-hydroxy-D-prolinol;1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE
• CAS NO: 141850-54-6
• Molecular Formula: C₁₀H₁₉NO₄
• Molecular Weight: 217.263
• Mol File: 141850-54-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 340.296°C at 760 mmHg
• Flash Point: 159.605°C
• Appearance: /
• Density: 1.190
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE(141850-54-6)
• EPA Substance Registry System: 1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE(141850-54-6)

Safety Data

• Hazardous Substances Data: 141850-54-6(Hazardous Substances Data)

Usage

General Description

1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE is a chemical compound that belongs to the class of pyrrolidines. It is a derivative of 4-hydroxy-2-pyrrolidinone. The compound is commonly used as a building block in the synthesis of pharmaceuticals and other organic molecules. The BOC (tert-butoxycarbonyl) group at the N-1 position is a protective group that can be removed under mild conditions to reveal the free amine, making it useful in organic synthesis. The (2R,4R) stereochemistry indicates the configuration of the chiral centers in the molecule, which is important for its biological activity and interactions with other molecules. Overall, 1-N-BOC-(2R,4R)-4-HYDROXY-2-(HYDROXYMETHYL) PYRROLIDINE is a versatile compound with various applications in the field of organic and medicinal chemistry.

InChI:InChI=1/C10H19NO4/c1-10(2,3)15-9(14)11-5-8(13)4-7(11)6-12/h7-8,12-13H,4-6H2,1-3H3/t7-,8-/m1/s1

Upstream product

• 2584-71-6 cis-hydroxy-D-proline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114676-47-0 (2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester 
• 14044-65-6 borane-THF 
• 135042-12-5 (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 114676-69-6 (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1572937-30-4 (2R,4R)-tert-butyl 4-((3-aminobenzyl)oxy)-2-(((3-aminobenzyl)oxy)methyl)pyrrolidine-1-carboxylate 
• 1572937-31-5 (2R,4R)-tert-butyl 4-((3-(thiophene-2-carboximidamido)benzyl)oxy)-2-(((3-(thiophene-2-carboximidamido)benzyl)oxy)methyl)pyrrolidine-1-carboxylate 
• 1572937-11-1 N-(3-((((2R,4R)-4-(((3-(thiophene-2-carboximidamido)benzyl)oxy)methyl)pyrrolidin-2-yl)oxy)methyl)phenyl)thiophene-2-carboximidamide 
• 1572937-29-1 (2R,4R)-tert-butyl 4-((3-nitrobenzyl)oxy)-2-(((3-nitrobenzyl)oxy)methyl)pyrrolidine-1-carboxylate 
• 1610035-87-4 (2R,4R)-tert-butyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)-4-hydroxypyrrolidine-1-carboxylate 
• 1610035-88-5 (2R,4R)-tert-butyl 2-(((tert-butyldiphenylsilyl)oxy)methyl)-4-(pentyloxy)pyrrolidine-1-carboxylate 
• 1338549-48-6 (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-carboxymethoxy-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 1338549-40-8 C₂₈H₃₆N₆O₆ 
• 1338549-44-2 C₂₈H₃₆N₆O₆ 
• 1338549-36-2 (2R,4R)-2-(N₃-benzoylthymine-1-ylmethyl)-4-tert-butoxycarbonylmethyoxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 1338549-28-2 (2R,4R)-4-tert-butoxycarbonylmethoxy-2-(4-tosyloxymethyl)-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 
• 143334-62-7 N-Boc-3(S)-<(5-carboxypentanoyl)oxy>-5(S)-<(tosyloxy)methyl>pyrrolidine 

Relevant articles and documents

SULFONAMIDE COMPOUNDS HAVING TNAP INHIBITORY ACTIVITY

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof.

PYRROLIDINE GPR40 MODULATORS FOR THE TREATMENT OF DISEASES SUCH AS DIABETES

The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.