133858-36-3

Upstream product

• 112519-67-2 1-p-tolyl-4-dimethylamino-2-thiomethyl-1,3-diazabutadiene 
• 103-80-0 phenylacetyl chloride 
• 112519-75-2 1-[1-Dimethylamino-meth-(E)-ylidene]-3-p-tolyl-thiourea 
• 112519-78-5 4-dimethylamino-2-methylsulfanyl-1-p-tolyl-1,3-diazabuta-1,3-dienium iodide 

Downstream Products

• 1262446-37-6 2-methylsulfonyl-5-phenyl-3-p-tolylpyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Synthesis of nitrogen bicyclic scaffolds: Pyrimido[1,2-a]pyrimidine-2,6- diones

The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a] pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/ cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.

[4+2] Cycloaddition reactions of various 1,3-diaza-1.3-butadienes with ketenes

[4+2] cycloaddition reactions of 1-aryl-4-dimethylainino-1,3-diaza-1, 3-butadienes (I), 1 -aryl-4-dimethylamino-2-methylthio-1, 3-diaza-1, 3-butadienes (5), 1-aryl-4-methylthio-2-phenyl-4-sec. amino-1, 3-diaza-1, 3-butadienes (9) and 4, 4-bis(sec.amino)-1