112519-67-2

Upstream product

• 112519-78-5 4-dimethylamino-2-methylsulfanyl-1-p-tolyl-1,3-diazabuta-1,3-dienium iodide 
• 112519-75-2 1-[1-Dimethylamino-meth-(E)-ylidene]-3-p-tolyl-thiourea 
• 74-88-4 methyl iodide 
• 112519-75-2 4-dimethylamino-2-p-tolylamino-1,3-thiazabuta-1,3-diene 

Downstream Products

• 142779-67-7 5-p-chlorobenzoylamino-4-dimethylamino-5-methyl-2-methylthio-1-p-tolyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 142779-68-8 5-benzoylamino-4-dimethylamino-5-methyl-2-methylthio-1-p-tolyl-1,4,5,6-tetrahydropyrimidin-6-one 
• 133858-36-3 5-phenyl-2-methylthio-1-p-tolyl-1,6-dihydropyrimidin-6-one 
• 133858-56-7 5-chloro-2-methylthio-1-p-tolyl-1,6-dihydropyrimidin-6-one 
• 112519-71-8 2-p-tolyl-5-dimethylamino-3-thiomethyl-1,2,4-thiadiazine-1,1-dioxide 

Relevant academic research and scientific papers

Synthesis of nitrogen bicyclic scaffolds: Pyrimido[1,2-a]pyrimidine-2,6- diones

The multi-step synthesis of 1,3,7-trisubstituted pyrimido[1,2-a] pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/ cyclocondensation reactions. [4+2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.

[4+2] Cycloaddition reactions of various 1,3-diaza-1.3-butadienes with ketenes

[4+2] cycloaddition reactions of 1-aryl-4-dimethylainino-1,3-diaza-1, 3-butadienes (I), 1 -aryl-4-dimethylamino-2-methylthio-1, 3-diaza-1, 3-butadienes (5), 1-aryl-4-methylthio-2-phenyl-4-sec. amino-1, 3-diaza-1, 3-butadienes (9) and 4, 4-bis(sec.amino)-1

Synthesis of Functionally Substituted 1,3-Diaza-1,3-butadienes

Three methods for the synthesis of various stable 1,3-diaza-1,3-butadienes from easily available thiourea derivatives are reported.

DIELS-ALDER CYCLOADDITION REACTIONS OF 1,3-DIAZABUTADIENES WITH SULFENE

Diels-Alder cycloaddition reactions of 1-aryl-4-dimethylamino-2-phenyl(thiomethyl)-1,3-diazabutadienes with sulfene resulting in good yields of 1,2,4-thiadiazine-1,1-dioxide derivatives are reported.