1338586-40-5

Upstream product

• 1208-03-3 4-(bis(2-chloroethyl)amino)benzaldehyde 
• 72700-11-9 4-(bis(2-iodoethyl)amino)benzaldehyde 
• 120-07-0 2,2'-(phenylimino)bis[ethanol] 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 1335107-24-8 (5,5'-(thiobis(methylene))bis(2,2-dimethyl-1,3-dioxane-5,5-diyl))dimethanethiol 
• 1335107-23-7 bis((5-((benzylthio)methyl)-2,2-dimethyl-1,3-dioxan-5-yl)methyl)sulfane 
• 1335107-43-1 (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 4-(3-(4-cyanophenyl)-5-(4-(3,3,13,13-tetramethyl-2,4,12,14-tetraoxa-8,17,23-trithia-20-azadispiro[5.3.5.9]tetracosan-20-yl)phenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonate 
• 1335107-37-3 (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 4-fluorobenzene-1-sulfonate 
• 1335107-40-8 (2,2,5-trimethyl-1,3-dioxan-5-yl)methyl 4-hydrazinylbenzenesulfonate 
• 1335107-26-0 4-(3-(4-(3,3,13,13-tetramethyl-2,4,12,14-tetraoxa-8,17,23-trithia-20-azadispiro[5.3.5.9]tetracosan-20-yl)phenyl)prop-2-enoyl)benzonitrile 
• 1335107-25-9 4-(3,3,13,13-tetramethyl-2,4,12,14-tetraoxa-8,17,23-trithia-20-azadispiro[5.3.5.9]tetracosan-20-yl)benzaldehyde 

Relevant academic research and scientific papers

Designed to dissolve: Suppression of colloidal aggregation of Cu(I)-selective fluorescent probes in aqueous buffer and in-gel detection of a metallochaperone

Due to the lipophilicity of the metal-ion receptor, previously reported Cu(I)-selective fluorescent probes form colloidal aggregates, as revealed by dynamic light scattering. To address this problem, we have developed a hydrophilic triarylpyrazoline-based fluorescent probe, CTAP-2, that dissolves directly in water and shows a rapid, reversible, and highly selective 65-fold fluorescence turn-on response to Cu(I) in aqueous solution. CTAP-2 proved to be sufficiently sensitive for direct in-gel detection of Cu(I) bound to the metallochaperone Atox1, demonstrating the potential for cation-selective fluorescent probes to serve as tools in metalloproteomics for identifying proteins with readily accessible metal-binding sites.