1338587-04-4

Basic information

• Product Name: (S)-tert-butyl 3-(((S)-1-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
• Synonyms: (S)-tert-butyl 3-(((S)-1-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
• CAS NO: 1338587-04-4
• Molecular Weight: 551.683
• Mol File: 1338587-04-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-tert-butyl 3-(((S)-1-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 3-(((S)-1-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate(1338587-04-4)
• EPA Substance Registry System: (S)-tert-butyl 3-(((S)-1-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate(1338587-04-4)

Safety Data

• Hazardous Substances Data: 1338587-04-4(Hazardous Substances Data)

Upstream product

• 77497-95-1 (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride 
• 38155-45-2 methyl L-phenylalanyl-L-leucinate hydrochloride 
• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 
• 63-91-2 L-phenylalanine 

Downstream Products

• 1338587-27-1 (S)-tert-butyl 3-(((S)-1-(((S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1338586-94-9 (S)-N-((S)-1-(((S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors

A series of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives were designed, synthesized and assayed for their activities against aminopeptidase N (APN/CD13) and MMP-2. The results showed that most compounds exhibited higher inhibitory activities against APN than that of MMP-2. Within this series, compound 12h (IC50 = 6.28 ± 0.11 μM) showed similar inhibitory activities compared with Bestatin (IC50 = 5.55 ± 0.01 μM), and it could be used as novel lead compound for the future APN inhibitors development as anticancer agents.