133863-87-3

Basic information

• Product Name: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE
• Synonyms: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE;2-methoxy-6-(trifloromethyl)aniline
• CAS NO: 133863-87-3
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191
• Mol File: 133863-87-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 221.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.280±0.06 g/cm3(Predicted)
• PKA: 1.40±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE(133863-87-3)
• EPA Substance Registry System: 2-METHOXY-6-(TRIFLUOROMETHYL)ANILINE(133863-87-3)

Safety Data

• Hazardous Substances Data: 133863-87-3(Hazardous Substances Data)

Usage

General Description

2-Methoxy-6-(trifluoromethyl)aniline, also known as trifluoromethoxyaniline, is an aromatic amine containing a methoxy group and a trifluoromethyl group. It is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is also utilized in the production of dyes and pigments, as well as in the synthesis of various organic compounds. It is important to handle 2-methoxy-6-(trifluoromethyl)aniline with care as it is toxic if ingested, inhaled, or in contact with skin. It is also harmful to aquatic life and can have long-term effects on the environment. Proper safety and handling precautions should be followed when working with this chemical.

Upstream product

• 386-72-1 2-nitro-3-(trifluoromethyl)phenol 
• 887144-94-7 Togni's reagent II 
• 90-04-0 2-methoxy-phenylamine 
• 454-90-0 3-(trifluoromethyl)anisole 

Downstream Products

• 147150-36-5 N-(2-Methoxy-6-(trifluoromethyl)phenyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide 
• 116314-60-4 4-hydroxy-3-methoxy-5-(trifluoromethyl)benzaldehyde 
• 116314-59-1 2-hydroxy-3-(trifluoromethyl)anisole 
• 1272528-80-9 4-hydroxy-3-methoxy-5-(trifluoromethyl)benzoic acid 
• 1272528-81-0 3,4-dihydroxy-5-(trifluoromethyl)benzoic acid 
• 1272528-82-1 3,4-diisopropoxy-5-(trifluoromethyl)benzoic acid 
• 914635-64-6 2-bromo-1-methoxy-3-(trifluoromethyl)benzene 

Relevant articles and documents

A practical synthesis of 2-methoxy-6-trifluoromethylaniline

A practical synthesis of 2-methoxy-6-trifluoromethylaniline is described via halogenation, nitration and reduction of 3-trifluoromethylanisole.

Preparation method of trifluoromethylamine

The invention relates to a preparation method of trifluoromethylamine. The method includes the following steps that aromatic amine shown in the formula (1) and a trifluoromethyl reagent shown in the formula (2) react in a solvent under the condition that an alkali and/or nickel compound exists, and the trifluoromethylamine compound shown in the formula (3) is generated. According to the preparation method of trifluoromethylamine, aromatic amine and 1-trifluoromethyl-1,2-iodobenzoyl-3(H)-ketone serve as raw materials and react under the condition that the alkali and/or nickel compound exists through the amino positioning effect on aromatic nucleus. The synthesis steps of the method are simple, the cost of the raw materials is low, the production cost of trifluoromethylamine can be greatly reduced, and large-scale industrialized production is promoted.

THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, a