13388-94-8

Usage

Uses

Used in Pharmaceutical Synthesis:
Spiro[4.5]decan-6-one is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic properties.
Used in Fragrance Industry:
In the fragrance industry, Spiro[4.5]decan-6-one is used as a scent component to create floral and fruity scents, capitalizing on its distinct odour profile to enhance the sensory experience of consumer products.
Used in Organic Synthesis:
As a building block in organic synthesis, Spiro[4.5]decan-6-one is utilized for the development of new materials and complex organic compounds, taking advantage of its reactive ketone group to form diverse molecular architectures.
Used in Material Development:
Spiro[4.5]decan-6-one also finds application in the development of new materials, where its unique structural features can contribute to the creation of innovative and improved material properties.

InChI:InChI=1/C10H16O/c11-9-5-1-2-6-10(9)7-3-4-8-10/h1-8H2

Upstream product

• 51953-08-3 2-(4-bromo-butyl)-cyclohexanone 
• 110-52-1 1,4-dibromo-butane 
• 108-94-1 cyclohexanone 
• 14054-26-3 spiro[4.5]dec-2-en-6-one 
• 5181-75-9 bicyclopentyl-1,1'-diol 
• 73429-76-2 bis 
• 75567-25-8 1-bromo-1'-hydroperoxycyclopentylcyclopentane 
• 105-36-2 ethyl bromoacetate 
• 5811-94-9 4A,8a-epoxy-decahydro-naphthalene 
• 71-43-2 benzene 
• 7664-93-9 sulfuric acid 
• 103724-57-8 1-(4-Iodobutyl)cyclopentanecarboxylic acid, methyl ester 
• 57289-63-1 (4ar,8ar)-octahydronaphthalene-4a,8a-diol 
• 4630-80-2 methyl cyclopentane carboxylate 

Downstream Products

• 6604-12-2 Dispiro<4,1,4,3>tetradecan-6-on 
• 343834-66-2 <2-(Dimethylaminomethyl)phenyl>-<(6-hydroxy-spiro<4.5>dec-6-yl)methyl>-sulfoxid 
• 120385-04-8 6-benzylspiro<4.5>decan-6-ol 
• 825-25-2 2-cyclopentylidenecyclopentan-1-one 
• 6274-52-8 4-(1-carboxy-cyclopentyl)-butyric acid 
• 739-08-2 spiro[4.5]decan-6-one p-toluenesulfonylhydrazone 

Relevant academic research and scientific papers

Synthesis and fungicidal activity of substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols

A series of halogen substituted 6-azolylmethyl-7-benzylidenespiro[4.5]decan-6-ols were obtained from spiro[4.5]decan-6-one in three steps: Claisen—Schmidt condensation with substituted benzaldehydes, conversion of 7-benzylidenespiro[4.5]decan-6-ones to ox

Zirconium complexes bearing η5-5′,6′,7′- trihydrospiro[cycloalkane-1,4′-indenyl] ligands

Tetrahydroindenes including spiro-cyclopentyl and -cyclohexyl fragments were successfully synthesized either via base-catalyzed cyclization of the respective γ-diketone or via acid-catalyzed Nazarov cyclization of the corresponding divinylketones. These substituted cyclopentadienes were metallated with nBuLi. The following reaction of the lithium salts with Cp (*)ZrCl3 gave three novel zirconocenes bearing spiro-cycloalkane fragments. One of these complexes, (η5- 5′,6′,7′-trihydrospiro[cyclohexane-1,4′-(2- methylindenyl)])(η5-pentamethyl-cyclopentadienyl)zirconium dichloride, has been characterized by X-ray crystal structure analysis. Tetrahydroindenes including spiro-cyclopentyl and -cyclohehyl fragments were successfully synthesized either via base-catalyzed cyclization of the respective γ-diketone or via acid-catalyzed Nazarov cyclization of the corresponding divinylketones. These substituted cyclopentadienes were metallated with nBuLi. The following reaction of the lithium salts with Cp (*)ZrCl3 gave three novel zirconocenes bearing spiro-cycloalkane fragments.

SPIRO KETONE SYNTHESIS VIA LITHIUM-IODINE EXCHANGE OF α-(ω-IODOALKYL) ESTERS

The title reaction (2 eq. of t-BuLi, -100 deg C) provides a new route to five- and six-membered ring ketones and has permitted the synthesis of two spiro ketones that were inaccessible by conventional methods.

Renewable high-density spiro-fuels from lignocellulose-derived cyclic ketones

Renewable high-density spiro-fuels are synthesized from lignocellulose-derived cyclic ketones for the first time, which show higher density, higher neat heat of combustion and lower freezing point compared with other biofuels synthesized from the same feedstock, and thus represent a new type of renewable high-density fuel attractive for practical applications.

Pinacol Rearrangement and Direct Nucleophilic Substitution of Allylic Alcohols Promoted by Graphene Oxide and Graphene Oxide CO2H

Graphene oxide (GO) and carboxylic acid functionalized GO (GO–CO2H) have been found to efficiently promote the heterogeneous and environmentally friendly pinacol rearrangement of 1,2-diols and the direct nucleophilic substitution of allylic alcohols. In general, high yields and regioselectivities are obtained in both reactions using 20 wt % of catalyst loading and mild reaction conditions.

Palladium catalyzed synthesis of some novel (Spirocycloalkenyl) trimethylsilylacetylenes

The synthesis of some novel (spirocycloalkenyl)trimethylsilylacetylenes employing the Sonogashira coupling reaction of the corresponding novel spirocycloalkenyliodides with trimethylsilylacetylene and Pd(PPh3)2Cl2/CuI catalyst in yields ranging 79-84% is reported. The compounds would serve as novel (spirocycloalkenyl)acetylenic anionic synthons.

INHIBITORS OF INFLUENZA VIRUSES REPLICATION

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

An unexpected directing effect in the asymmetric transfer hydrogenation of α,α-disubstituted ketones

α,α-Disubstituted ketones containing an aromatic ring or alkene are reduced in high enantiomeric excess using an asymmetric transfer hydrogenation catalyst. The sense of reduction indicates that the unsaturated region of the ketone adopts a position adjacent to the Ru-bound η6-arene ring in the reduction transition state.

Polymer-mediated pinacol rearrangements

Both poly(3,4-ethylenedioxythiophene) and poly(pyrrole) mediate a pinacol rearrangement of 1,2-diols. The yields of ketone or aldehyde products are comparable to those observed for treatment with mineral acids or Lewis acids. The advantage of this protocol is a two-phase reaction medium in hydrocarbon solvents that allows facile recovery of the products by simple filtration of the polymer and removal of solvents. Both the polymer and the hydrocarbon solvent may be recovered and used in subsequent reactions. Georg Thieme Verlag Stuttgart · New York.

AMINO HETEROCYCLIC LINKED PYRIMIDINE DERIVATIVES

Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.