1338832-17-9Relevant academic research and scientific papers
Intramolecular Povarov reactions involving 3-aminocoumarins
Kudale, Amit A.,Miller, David O.,Dawe, Louise N.,Bodwell, Graham J.
supporting information; experimental part, p. 7196 - 7206 (2011/10/31)
A series of pentacyclic heterocyclic systems (15 examples, 69-89%) have been synthesized using intramolecular Povarov reactions involving 3-aminocoumarins and O-cinnamylsalicylaldehydes. The Povarov adducts are formed with high selectivity for the trans,trans relative stereochemistry in the newly-formed [6,6] fused ring system. One example of a Povarov adduct featuring a new [6,5] fused ring system is reported. In this case, cis,trans relative stereochemistry was preferred.
