1338916-51-0

Basic information

• Product Name: 2-(1-(4-tolyl)-4-(trimethylsilyl)-1H-1,2,3-triazol-5-yl)pyridine
• CAS NO: 1338916-51-0
• Molecular Weight: 308.458
• Mol File: 1338916-51-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-(4-tolyl)-4-(trimethylsilyl)-1H-1,2,3-triazol-5-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-(4-tolyl)-4-(trimethylsilyl)-1H-1,2,3-triazol-5-yl)pyridine(1338916-51-0)
• EPA Substance Registry System: 2-(1-(4-tolyl)-4-(trimethylsilyl)-1H-1,2,3-triazol-5-yl)pyridine(1338916-51-0)

Safety Data

• Hazardous Substances Data: 1338916-51-0(Hazardous Substances Data)

Upstream product

• 1066-54-2 trimethylsilylacetylene 
• 106-49-0 p-toluidine 
• 2101-86-2 p-methylazidobenzene 
• 86521-05-3 2-(trimethylsilylethynyl)pyridine 

Relevant articles and documents

Metal-free 1,5-regioselective azide-alkyne [3+2]-cycloaddition

[3+2]-cycloaddition reactions of aromatic azides and silylated alkynes in aqueous media yield 1,5-disubstituted-4-(trimethyl-silyl)-1H-1,2,3-triazoles. The formation of the 1,5-isomer is highly favored in this metal-free cycloaddition, which could be proven by 1D selective NOESY and X-ray investigations. Additionally, DFT calculations corroborate the outstanding favoritism regarding the 1,5-isomer. The described method provides a simple alternative protocol to metal-catalyzed "click chemistry" procedures, widening the scope for regioselective heavy-metal-free synthetic applications.