1338921-55-3

Basic information

• Product Name: N-(4-fluorobenzyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-5-carboxamide
• Synonyms: N-(4-fluorobenzyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-5-carboxamide
• CAS NO: 1338921-55-3
• Molecular Weight: 681.718
• Mol File: 1338921-55-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-fluorobenzyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorobenzyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-5-carboxamide(1338921-55-3)
• EPA Substance Registry System: N-(4-fluorobenzyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine-5-carboxamide(1338921-55-3)

Safety Data

• Hazardous Substances Data: 1338921-55-3(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 104375-88-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine 
• 140-75-0 para-fluorobenzylamine 
• 186553-11-7 5'-O-DMT-5-(2,2,2-trifluoroethyloxy-carbonyl)-2'-deoxyuridine 

Downstream Products

• 1338921-60-0 5'-O-(4,4'-dimethoxytrityl)-5-(4-fluorobenzylaminocarbonyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphinyl]-2'-deoxyuridine 
• 1338921-65-5 5-(4-fluorobenzylaminocarbonyl)-3'-O-acetyl-2'-deoxyuridine 

Relevant articles and documents

Pd/PTABS: An Efficient Catalytic System for the Aminocarbonylation of a Sugar-Protected Nucleoside

A highly efficient and mild protocol for the aminocarbonylation of a nucleoside is developed by employing palladium/(1,3,5-Triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate (Pd/PTABS) as the catalytic system. The developed aminocarbonylation methodology employs CO gas at a relatively low temperature of 60? °C and is suitable for a wide range of amines, including (heteroaryl)benzylic, aliphatic acyclic, alicyclic and secondary amines. This protocol is also utilized for the synthesis of a sangivamycin precursor by carrying out the Pd-catalyzed amination and aminocarbonylation simultaneously. The utility of this protocol is further demonstrated by the synthesis of the drugs moclobemide and nikethamide.