1338939-07-3Relevant academic research and scientific papers
Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone
Kenis, Sara,D'Hooghe, Matthias,Verniest, Guido,Nguyen, Vinh Duc,Thi, Tuyet Anh Dang,Nguyen, Tuyen Van,Kimpe, Norbert De
, p. 7217 - 7223 (2011/11/06)
An efficient and straightforward approach towards the synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone via imination, α-chlorination, hydride reduction and ring closure was developed. In addition, novel primary β-iodo amines were obtained by regioselective ring opening of these 2-(trifluoromethyl)aziridines using alkyl iodides, and their synthetic potential was demonstrated by converting them into novel α-CF3-β-phenylethylamines upon treatment with lithium diphenylcuprate.
