119561-23-8

Basic information

• Product Name: N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE
• Synonyms: N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE
• CAS NO: 119561-23-8
• Molecular Formula: C₁₀H₁₀F₃N
• Molecular Weight: 201.19
• Mol File: 119561-23-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 84 °C
• Flash Point: 63.1°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 1.2mmHg at 25°C
• Refractive Index: 1.449
• CAS DataBase Reference: N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE(119561-23-8)
• EPA Substance Registry System: N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE(119561-23-8)

Safety Data

• Hazardous Substances Data: 119561-23-8(Hazardous Substances Data)

Usage

Description

N-(1-Trifluoromethyl-ethylidene)benzylamine, a chemical compound with the formula C9H9F3N, is a member of the benzylamine derivatives class. It is recognized for its ability to participate in a range of chemical reactions, including alkylation, acylation, and reduction, due to its unique trifluoromethyl group. N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE is instrumental in the development of new drugs and materials, and it is also utilized in the production of specialty chemicals and as an intermediate in pharmaceutical synthesis.

Uses

Used in Organic Synthesis:
N-(1-Trifluoromethyl-ethylidene)benzylamine is used as a reagent in organic synthesis for its capacity to engage in various chemical reactions, which is crucial for creating a multitude of organic compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(1-Trifluoromethyl-ethylidene)benzylamine serves as a valuable component due to its potential role in the development of new drugs, leveraging its unique chemical properties to enhance drug efficacy and target specific biological pathways.
Used in the Production of Specialty Chemicals:
N-(1-TRIFLUOROMETHYL-ETHYLIDENE)BENZYLAMINE is utilized in the creation of specialty chemicals, where its distinctive trifluoromethyl group contributes to the unique characteristics of the final products, catering to specific industrial needs.
Used as an Intermediate in Pharmaceutical Compound Synthesis:
N-(1-Trifluoromethyl-ethylidene)benzylamine is employed as an intermediate in the synthesis of pharmaceutical compounds, playing a key role in the production of various medications by facilitating the formation of desired molecular structures.

InChI:InChI=1/C10H10F3N/c1-8(10(11,12)13)14-7-9-5-3-2-4-6-9/h2-6H,7H2,1H3/b14-8+

Upstream product

• 421-50-1 1,1,1-trifluoro-2-propanone 
• 100-46-9 benzylamine 
• 1522-22-1 1,1,1,5,5,5-hexafluoroacetylacetone 
• 52826-45-6 (benzylimino)triphenylphosphorane 

Downstream Products

• 1098215-26-9 2-[benzyl(trifluoroacetyl)amino]-N-(tert-butyl)-3,3,3-trifluoro-2-methylpropanamide 
• 1098215-23-6 N-benzyl-2-[benzyl(trifluoroacetyl)amino]-3,3,3-trifluoro-2-methylpropanamide 
• 1098215-41-8 ethyl 2-({2-[benzy(trifluoroacetyl)amino]-3,3,3-trifluoro-2-methylpropanoyl}amino)propanoate 
• 1098215-42-9 diethyl 2-{2-[benzy(trifluoroacetyl)amino]-3,3,3-trifluoro-2-methylpropanoyl}glutamate 
• 421-49-8 2,2,2-Trifluoro-1-methylethanamine 
• 106240-89-5 N-benzyl-2-(trifluoromethyl)aziridine 
• 1338939-09-5 N,N-dibenzyl-1,1,1-trifluoro-3-phenylpropan-2-amine 
• 1338939-07-3 N-benzyl-1,1,1-trifluoro-3-iodo-N-methylpropan-2-amine 
• 1338939-04-0 N,N-dibenzyl-1,1,1-trifluoro-3-iodopropan-2-amine 
• 1338939-11-9 2-benzylamino-3,3,3-trifluoropropyl acetate 
• 1338938-96-7 C₁₀H₁₁ClF₃N 
• 1338938-93-4 N-(1-chloromethyl-2,2,2-trifluoroethylidene)benzylamine 
• 1254973-77-7 (Z)-4-(benzylamino)-1,1,5,5,5-pentafluoro-2-oxopent-3-ene-1-sulfonyl fluoride 
• 119561-24-9 N-benzylidene(1,1,1-trifluoroisopropyl)amine 

Relevant articles and documents

New synthetic access to 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids

A novel process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids is hereby presented. Easily accesible α-fluorinated ketimines were condensed with oxalyl monochloride derivatives, and the obtained vinamides underwent acid-catalyzed cyclization with substituted hydrazines. This highly efficient protocol can also be used for non-fluorinated C-3 and C-5 substituents.

PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLE DERIVATIVES FROM α,α-DIHALOAMINES AND KETIMINES

Process for preparine3,5-bis(haloalkyl)pyrazolederivatives from a,a-dihaloamines and ketimines The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines. Intermedaites used in the process are also claimed.

Chemoenzymatic dynamic kinetic resolution of α-trifluoromethylated amines: Influence of substitutions on the reversed stereoselectivity

Enzymatic resolution of α-trifluoromethylated amines via kinetic resolution (KR), dynamic kinetic resolution (DKR) employing CALB-Pd/Al 2O3, and a one-pot sequential process of KR/DKR/KR was investigated comparatively for the first time. Although CALB-catalyzed KR of α-trifluoromethylated amines with substituents of methyl (1a), isopropyl (1c), phenyl (1d) and benzyl group (1e) can provide good stereoselectivity factors E from 31 to >200 respectively, DKR and sequential process of KR/DKR/KR possess better practical application potential because of the higher conversion (62%-84%) and the similar enantiomeric excesses (90%-99%). The enantiopreference and inversion for the α-trifluoromethylated amines displayed by CALB were observed and explained by docking modes. Namely, for 1,1,1-trifluoro-2-propylamine (1a), the product amide with R-configuration was obtained, and the enantiopreference was converted to S for the amines (1b-1e) with substituents larger than methyl group. The catalysts recycle, and scale-up experiments were demonstrated successfully. All these results indicated the high efficiency and green feature of this enzymatic process, and its application significance.